Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 79 years old.
• You have been found to have multiple small spots (nodules) in your lungs on a CT scan — between 2 and 5 nodules of a specific size, spread across at least two different sections of your lungs.
• At least one of your lung nodules has been confirmed as lung cancer through a tissue test (biopsy), and any remaining nodules have been stable on CT scans for at least 3 months after a course of anti-inflammatory treatment.
• Your cancer has not spread to your lymph nodes or any other part of your body.
• You are generally able to carry out some or all of your normal daily activities (this is measured on a standard scale called ECOG, scored 0–2) (confirm with trial site).
• Your doctors expect you to live for at least 12 more months.
• Your blood counts are at an acceptable level — including enough white blood cells, platelets, and red blood cells (confirm with trial site for exact values).
• Your liver is working well enough, based on blood test results (confirm with trial site for exact values).
• Your kidneys are working well enough, based on a calculation of how well they filter your blood (confirm with trial site for exact values).
• Your blood's ability to clot is within an acceptable range, or if you are on blood-thinning medication, your levels are within the recommended range for that medication.
• If you are a woman who could become pregnant, you must have a negative pregnancy test (urine or blood) within 3 days before starting treatment.
• If there is any chance you could father or become pregnant, you and your partner must use a highly effective form of contraception during the trial and for at least 180 days after finishing treatment.
• You are willing to take part, are able to attend follow-up appointments, and have signed a written consent form before any trial procedures begin.

Who may not be able to join:

• Your tumour has been found to have certain specific genetic changes (mutations in EGFR, ALK, ROS1, BRAF V600E, or NTRK) (confirm with trial site).
• Any of your lung nodules is larger than 30mm (about 3cm) on scans taken before treatment.
• Your scans or lymph node tests before treatment suggest that cancer has already spread to your lymph nodes.
• Tests before treatment show that your cancer has spread to other parts of your body, or there is fluid build-up in your chest or abdomen.
• You are currently in another clinical trial, or have taken an experimental drug or used an experimental device within the last 3 months.
• You have had any anti-cancer treatment before the procedure planned in this trial — such as chemotherapy, radiotherapy, targeted therapy, or certain immune-boosting medicines — or you have had major surgery within 3 weeks before the first procedure.
• You have previously been treated with certain types of immunotherapy drugs, including anti-PD-1, anti-PD-L1, anti-PD-L2, or similar therapies that affect your immune system's T cells (confirm with trial site for specific drug names).
• You have conditions that could make surgery or a procedure called ablation unsafe, such as blood clotting problems or immune system diseases.
• You have abnormal blood clotting results, a tendency to bleed (for example, an active stomach ulcer), or you are currently on clot-dissolving or blood-thinning medication.
• You have had a significant bleeding episode in your lungs or elsewhere in your body within the 4 weeks before the first procedure (confirm with trial site for severity definitions).
• You have a known HIV infection, syphilis, active tuberculosis, or untreated active hepatitis.
• You have severe problems with your heart, liver, or kidney function (confirm with trial site for exact definitions).
• You have a known mental health condition or substance misuse issue that might make it difficult to follow the trial requirements.
• You have or have had another type of cancer or a blood disorder.
• You are pregnant, planning to become pregnant, or currently breastfeeding.
• The trial doctor decides, for any other reason, that the trial is not appropriate for you.

Important: Always verify eligibility with the trial site directly before applying.