Phase 2 Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with multiple sclerosis (MS, any type) for at least six months, confirmed by an MS neurologist using recognised diagnostic guidelines
• People who have had muscle stiffness or spasms (spasticity) caused by MS for at least one month, which has not been adequately relieved by current treatments, and rates at 4 or higher on a pain/symptom scale of 0–10
• People who have been on a stable dose of their current MS treatments for at least 30 days before the initial screening appointment, and who are willing to keep those treatments unchanged throughout the study
• People aged 21 years or older
• People who, in the trial investigator's opinion, are able and willing to follow all study requirements
• People who can speak and read French or English at approximately a grade-nine level

Who may not be able to join:

• People who have another condition (besides MS) that causes or affects muscle spasticity
• People who have received botulinum toxin (e.g. Botox) injections within the four months before screening, or who are unwilling to stop receiving these injections for the duration of the study
• People who have used cannabis or cannabis-based medicines within seven days of entering the study, or who are unwilling to avoid these for the duration of the study
• People with a history of schizophrenia, psychosis, or other significant psychiatric conditions (not including anxiety or depression related to their MS)
• People with a history of alcohol or substance use disorder (not including nicotine use)
• People with a history of epilepsy or recurring seizures
• People with a known allergy or sensitivity to cannabinoids or any ingredient in the study medication
• People who have had a significant heart condition or heart-related problem in the past 12 months, or who have a heart condition that the investigator believes could put them at risk of a serious heart event
• People whose kidneys are not functioning well enough (as measured by a specific blood test result below a set level) (confirm with trial site)
• People with significantly reduced liver function or abnormal liver test results that are three times or more above the normal range
• People who are pregnant or breastfeeding
• Men with a history of fertility problems who plan to try to conceive at any point in the future
• People who plan to try to conceive either at the time of screening or while enrolled in the study
• People who are unwilling or unable to use an acceptable form of contraception throughout the entire study (applies to both women who could become pregnant and men)
• People who have any other significant illness or condition that the investigator believes could put them at risk, affect the study results, or affect their ability to take part
• People who plan to travel internationally or donate blood during the study period

Important: Always verify eligibility with the trial site directly before applying.