Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older
• People who have signed and dated a consent form and are willing to follow all study procedures for the full duration of the trial
• People whose general health and ability to carry out daily activities meets a minimum level, as measured by a standard medical scoring scale called the Karnofsky scale (score of 60 or above)
• People who have a confirmed cancer diagnosis (either a primary tumour or one that has spread from elsewhere in the body), based on tissue testing
• People who are able to take steroid medications
• People who are able to have an MRI scan (no medical reasons preventing this)
• People whose MRI scan shows a clearly defined, contrast-enhancing brain metastasis no larger than 4.0 cm that a specialist tumour board has recommended for surgical removal, and who have no more than 3 other brain metastases that could be treated with a focused type of radiation therapy
• People whose treating doctor estimates they have a life expectancy of more than 12 months
• People whose blood test results meet minimum levels for platelets, clotting function, and haemoglobin (confirm specific values with trial site)

Who may not be able to join:

• People whose cancer is of a type known as radiosensitive — specifically germ cell tumour, lymphoma, or multiple myeloma
• People showing signs of significant pressure building inside the skull that would require urgent surgery (such as a midline shift greater than 10 mm or compression of certain brain structures)
• People with more than 4 brain metastases in total, or whose metastasis being considered for removal is larger than 4.0 cm
• People who have more than one brain metastasis that would require surgical removal
• People with cancer that has spread to the lining or fluid surrounding the brain or spinal cord (unless it is in a limited area that can be treated with radiation at the same time as the surgery)
• People who have previously received radiation treatment to the brain, including focused radiation to the specific lesion being considered or whole-brain radiation
• People who have previously had surgery to remove a brain tumour (whether primary or secondary)
• People who have previously been diagnosed with a brain tumour other than a meningioma
• People who have received a radioactive (radionuclide) therapy within the past 30 days
• People who have received a type of cancer therapy targeting blood vessel growth (anti-VEGF therapy) within the past 6 weeks
• People who are unable to tolerate the positioning and treatment involved in focused radiation therapy
• People who are unable to give informed consent
• People who are pregnant or breastfeeding
• Women of reproductive potential who are not willing to use effective contraception for at least 6 months after radiation treatment
• Men of reproductive potential who are not willing to use effective contraception for at least 3 months after radiation treatment
• People who are unlikely to follow the study procedures and attend required follow-up appointments

Important: Always verify eligibility with the trial site directly before applying.