Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have brain metastases (cancer that has spread to the brain from another part of the body) confirmed by a special type of MRI scan using a contrast dye
• People who have at least one brain lesion that has grown back or worsened after previously being treated with focused radiation (called SRS) and/or surgery
• People whose target lesion has grown by at least 25% in size since previous treatment, based on standard measurement criteria
• People whose target lesion is small enough in size to be treated using a single laser probe during the planned procedure (maximum width of 3 cm), though using two probes during surgery may also be acceptable (confirm with trial site)
• People who are at least 3 months past their initial focused radiation (SRS) treatment of the target lesion
• People whose target lesion can safely undergo both a tissue sample (biopsy) and laser heat treatment (LITT), as determined by the treating brain surgeon
• People whose tissue sample can be assessed during surgery using a rapid laboratory technique called frozen pathology
• People whose symptoms have been stable for at least 3 days before the procedure, while taking no more than a set low daily dose of steroid medication (equivalent to 4mg of dexamethasone)
• People aged 18 or older
• People with a general health and functioning score of 70 or above on a standard medical scale (KPS), meaning they are able to care for themselves and carry out normal activities (confirm with trial site)
• People whose blood cell counts fall within acceptable levels, tested within 4 weeks before the biopsy — specifically, adequate white blood cell and platelet counts
• People whose kidney function blood test result falls within an acceptable range, tested within 4 weeks before the biopsy
• Female patients who have a negative pregnancy blood test before entering the study (this does not apply to those who have had both ovaries or the uterus removed, or who have gone through menopause)
• People of reproductive potential who agree to use an effective form of contraception throughout the study
• People who are able to attend follow-up visits as required by the study

Who may not be able to join:

• People who have more than 3 brain lesions that are actively growing at the time of joining the study
• People who have newly diagnosed brain metastases appearing at the same time as the target lesion being considered for treatment
• People who have received the drug bevacizumab within 4 weeks before starting the study
• People who are currently being actively treated for another cancer, with the exception of certain non-serious skin cancers or early-stage cervical cancer
• People who have a serious active infection or other significant health conditions that would prevent them from completing the study's quality-of-life questionnaires and thinking/memory assessments
• People who are unable to tolerate or have a medical reason not to take steroid medication (such as dexamethasone)
• People who the treating brain surgeon and/or radiation specialist considers unable to safely receive focused radiation (SRS) therapy
• People who have any condition that makes it unsafe for them to undergo a surgical procedure, as determined by their medical team
• People who are unwilling or unable to give their informed consent to participate
• People who are unable to meet the requirements of the study
• People who have cancer that has spread widely across the lining of the brain and spinal cord (called leptomeningeal disease)
• People whose cancer outside the brain is progressing rapidly

Important: Always verify eligibility with the trial site directly before applying.