Phase 2 Kidney Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 months and 40 years old at the time of enrollment
• You have one of the specific cancer types listed in the trial, such as neuroblastoma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, Wilms tumor, desmoplastic small round cell tumor, or another soft tissue sarcoma, at the required stage or relapse point (confirm with trial site for your specific diagnosis)
• You are well enough to carry out basic daily activities, as measured by a standard health performance score (confirm with trial site)
• Your body surface area (a measurement based on your height and weight) meets the minimum size requirement for the study drug dose
• You have recovered well enough from side effects of any previous cancer treatments
• Your blood counts (white cells, platelets, and red blood cells) are at acceptable levels
• Your kidneys are working well enough, based on blood and urine tests
• Your liver is functioning at an acceptable level, based on blood tests
• Your heart is healthy enough, with no serious heart rhythm problems, stroke, or heart attack in the past 6 months, and a normal heart electrical reading (ECG)
• Your blood pressure is within an acceptable range (you may be on one blood pressure medication at a stable dose)
• Your pancreas enzyme levels are within an acceptable range
• If you have seizures, you have been on a stable anti-seizure medication for at least 4 weeks that does not interfere with liver enzymes (confirm with trial site for approved medications)
• You have not had any invasive lung procedures or a collapsed lung within the past 4 weeks
• You have not had major surgery, serious infection, or significant physical trauma requiring hospitalization within the past 4 weeks
• Any surgical wounds or incisions are fully healed before enrollment
• You are able to swallow tablets whole — they cannot be cut or crushed
• If you are sexually active and able to have children, you and your partner agree to use approved contraception during the study and for 4 months after the last dose
• If you have had a period, you must confirm you are not pregnant at the time of enrollment
• You or your legal guardian are able to understand and agree to the study requirements and have signed the consent form
• You are able to start treatment within 12 weeks of finishing your most recent cancer therapy
• You are enrolled within 14 days of the imaging scans that confirmed your response to most recent treatment
• You are able to start treatment within 7 days of being enrolled in the study

Who may not be able to join:

• You do not have the specific cancer type or disease stage required by the trial
• Your general health or performance level does not meet the minimum required score
• You have not recovered sufficiently from side effects of previous treatments
• Your blood counts, kidney function, liver function, heart function, blood pressure, or pancreas enzyme levels do not meet the required levels
• You have had a serious heart event (such as a heart attack or stroke) within the past 6 months
• You are on certain anti-seizure medications that affect liver enzymes (confirm with trial site)
• You have had an invasive lung procedure or a collapsed lung within the past 4 weeks
• You have had major surgery, serious infection, or hospitalization due to trauma within the past 4 weeks
• You have had a central line or port placed, revised, or removed within the past 7 days (a PICC line is an exception — confirm with trial site)
• You have had a core or fine needle biopsy within the past 7 days
• You have surgical wounds or incisions that have not fully healed
• You are unable to swallow tablets whole
• You are pregnant or unwilling to use contraception during and after the study
• Additional exclusion criteria exist in the full protocol that are not listed here (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.