Phase 3 Endometrial Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older
• People who have been diagnosed with cervical cancer (confirmed by laboratory tissue testing) of a specific type — adenocarcinoma, adenosquamous, or squamous cell — at a certain stage of the disease (FIGO 2018 stage Ib3 to IIIc2) (confirm with trial site for staging details)
• People who have at least one tumour that can be measured using standard imaging criteria (RECIST 1.1)
• People who have not yet received any treatment for this cancer
• People with an expected survival of at least 3 months
• People who are generally well enough to carry out light activity or normal daily tasks, based on a standard performance scale (ECOG score of 0 or 1)
• People whose blood counts fall within acceptable ranges — including white blood cells, platelets, haemoglobin, and neutrophils — and who have no signs of bleeding problems
• People whose liver and kidney function test results are within acceptable limits set by the trial
• People whose heart is pumping blood effectively, with a heart function measurement (left ventricular ejection fraction) of 50% or above
• People who have voluntarily agreed to take part and have signed a consent form

Who may not be able to join:

• People who are pregnant or breastfeeding, or people of childbearing potential who are unwilling to use contraception during the trial (a negative pregnancy test within 7 days before the first dose is required)
• People who have, or have had, another type of cancer — except for certain fully cured skin cancers or non-invasive cancers (carcinoma in situ)
• People who have a bone marrow disorder or another condition affecting how the body produces blood cells
• People who have an active infection, HIV, or hepatitis that requires ongoing treatment
• People who already have nerve damage in their hands or feet (peripheral neuropathy), even at a mild level (Grade 1 or above)
• People who have experienced a serious heart or blood vessel problem within the past 6 months — such as a stroke, heart attack, uncontrolled high blood pressure, unstable chest pain, heart failure, or a heart rhythm problem requiring medication
• People with a known allergy to any of the study drugs or their ingredients
• People who have a significant thyroid condition at the time of enrolment
• People who have taken part in another cancer treatment clinical trial within the 30 days before starting this trial
• People with a known history of dementia, significant changes in mental state, or a mental health condition that would make it difficult to understand or consent to the study
• People whom the trial investigators consider unsuitable for participation for any other reason

Important: Always verify eligibility with the trial site directly before applying.