Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 10 and 30 years old
• You are able to speak and understand English
• You have been diagnosed with leukemia, aplastic anemia, bone marrow failure syndrome, or myelodysplastic syndrome, and received a bone marrow/stem cell transplant from a donor to treat it
• It has been between 6 and 48 months since your donor transplant
• If you are female, you must have a negative pregnancy test and agree to use an approved form of birth control (such as abstinence, condoms, or the pill) for the whole study
• You or your parent/guardian are willing and able to give permission to take part, and if you are a child, you are willing to agree to join
• You weigh at least 24 kg (about 53 pounds)

Who may not be able to join:

• You have a known allergy or sensitivity to a supplement called nicotinamide riboside (NR) (confirm with trial site)
• You are currently taking medications, including statins (cholesterol drugs), that could increase the risk of side effects from NR
• You currently have active cancer, have taken an experimental drug in the last 4 weeks, or are taking high-dose steroid medicines
• You already meet the public health guidelines for regular exercise
• You have taken high-dose NAD+ supplement products in the last 4 weeks (confirm with trial site)
• Your red blood cell levels (hemoglobin) are too low (below 10 g/dL)
• Your platelet count is too low (below 50,000)
• You have diabetes that requires insulin or certain diabetes medicines (confirm with trial site)
• Your blood sugar control is too poor, based on a blood test called HbA1c or a fasting blood sugar test (if you have diabetes, both tests must meet the required levels)
• You have kidney disease affecting how well your kidneys filter your blood
• You have liver disease, shown by certain liver enzyme levels being more than 3 times the normal range
• You have a physical condition that prevents you from doing exercise testing or training
• You have unstable chest pain or had a heart attack within 5 days of starting study activities
• You have frequent fainting episodes
• You have severe narrowing of the main heart valve (aortic stenosis) causing symptoms
• You have an uncontrolled irregular heartbeat that causes symptoms
• You had a blood clot in the lungs within the last 3 months
• You have a blood clot in the veins of your legs
• You have moderate or severe persistent asthma that causes symptoms, based on a breathing test done before your transplant
• Your blood oxygen level drops to 85% or below when resting and breathing normal air
• You are female and are pregnant or planning to become pregnant
• You have a non-heart or lung condition that could affect your ability to exercise or be made worse by exercise (for example, active infection, kidney failure, thyroid problems, or moderate-to-severe graft-versus-host disease causing physical problems)
• The trial team believes you or your parent/guardian may have difficulty following the study schedule or procedures
• You have a reason you cannot safely have an MRI scan (note: if you cannot complete the MRI, you may still be able to take part in other parts of the study — confirm with trial site)
• Your current weight means it would not be safe for you to complete the study activities

Important: Always verify eligibility with the trial site directly before applying.