Cervical Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with advanced cervical cancer (specific types: squamous cell carcinoma, adenocarcinoma, or adenosquamous cell carcinoma) that has been confirmed by tissue testing, is newly diagnosed, and falls within certain stages of spread — but has not reached the lymph nodes near the main artery of the spine (called paraaortic lymph nodes).
• People whose cancer has spread to pelvic lymph nodes, provided those affected nodes do not extend above a specific point where major blood vessels meet in the lower abdomen (confirm with trial site).
• People who have not had a hysterectomy (surgical removal of the uterus).
• People whose lymph node status in the pelvis has been assessed through one or more scans or biopsies, such as a PET/CT, CT, MRI, or tissue sampling procedure.
• People who are planning to receive pelvic radiation therapy combined with chemotherapy.
• People whose general health and ability to function meets a certain minimum level — rated as ECOG 0, 1, or 2 (or Karnofsky score of 60% or above), meaning someone who is able to carry out some daily activities even if limited by symptoms.
• People who are willing and able to complete several health and quality-of-life questionnaires as part of the study.
• People whose blood counts, liver function, and kidney function fall within the ranges required by the study (confirmed through blood tests before joining).
• People aged 18 or older, or who meet the local age of consent requirements.
• People who are already due to be prescribed a standard cisplatin chemotherapy treatment by their doctor.
• People who are able to understand the study and are willing to sign a written consent form.

Who may not be able to join:

• People who have previously had radiation therapy to the pelvis, abdomen, or paraaortic lymph node area, or who have received any prior treatment for this cervical cancer.
• People whose cancer has already spread to the paraaortic lymph nodes (the lymph nodes near the main artery along the spine).
• People who have already had a surgical procedure to remove pelvic and/or paraaortic lymph nodes.
• People who have previously had a bone marrow transplant from a donor or a solid organ transplant (such as a kidney or liver).
• People who have received systemic cancer treatments — such as chemotherapy, targeted therapy, or immunotherapy — for any cancer diagnosis within the past three years.
• People found on imaging or biopsy to have a second, unrelated cancer at the same time — with the exception of certain early-stage skin cancers or non-invasive breast changes (DCIS).
• People with a history of inflammatory bowel disease, such as ulcerative colitis or Crohn's disease.
• People with a history of certain autoimmune conditions, including rheumatoid arthritis, scleroderma, lupus, autoimmune vasculitis, Guillain-Barré syndrome, myasthenia gravis, or multiple sclerosis.
• People with currently active tuberculosis (TB).
• People who are pregnant.
• People who are currently breastfeeding and who do not agree to stop breastfeeding before treatment begins.
• People of childbearing potential who do not agree to use contraception during and for at least 14 months after the last cisplatin dose, in line with their treating institution's standard guidance.
• People with a known history or current diagnosis of an abnormal opening (fistula) between the bladder, bowel, or colon and the vagina.
• People who have had pelvic or paraaortic lymph node removal surgery before starting the planned chemotherapy and radiation treatment.
• People with a known active HIV infection.
• People who have hip replacement implants (prosthetics).

Important: Always verify eligibility with the trial site directly before applying.