Phase 1 Cervical Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Women aged 18 to 49 who have been infected with a specific strain of HPV called HPV16, and whose cervical cell test results show either normal cells or only mild/low-grade changes
• People whose HPV16 infection has been confirmed by two separate validated tests, taken at least 3 months apart
• People who have had a satisfactory colposcopy (a close-up examination of the cervix)
• People whose blood tests show no significant problems with blood counts, kidney function, or liver function
• People whose heart trace (ECG) reading is normal or has no significant concerns, as judged by the doctor running the trial
• People who have a negative pregnancy blood test at the screening visit
• People who agree to use a reliable form of contraception for the entire duration of the study
• People who have provided written consent to participate in the trial

Who may not be able to join:

• People who have received any vaccine within 6 weeks before the first study day
• People who have had an active significant viral infection (such as influenza, CMV, or EBV) within 30 days before receiving the study treatment
• People who also have hepatitis B, hepatitis C, or HIV, or who have any other condition that weakens the immune system
• People who currently have a bacterial vaginal infection known as bacterial vaginosis
• People who currently have higher-grade cervical cell changes (known medically as CIN2 or CIN3)
• People who have a current or past history of certain more serious cervical or gynaecological cell changes, or any suspicion of early or invasive cancer
• People who are currently pregnant or breastfeeding
• People who have had a flu-like illness within 3 months before the first study day
• People who have a known allergy or sensitivity to the drug oseltamivir (Tamiflu) or any of its ingredients
• People who have a physical condition of the cervix — such as from previous cervical surgery, a birth difference, or another condition — that would prevent a complete cervical examination
• People who currently have pelvic inflammatory disease, cervical inflammation, or another gynaecological infection detected during examination
• People who have a serious ongoing medical condition, including an active infection that requires treatment
• People who have an active or long-term bleeding or clotting disorder, or who have taken blood-thinning medication within 2 weeks before the first study day
• People who have a confirmed or suspected autoimmune disease
• People whose immune system is suppressed, including those taking ongoing steroid medications or immunosuppressive drugs (certain treatments for airway, ear, or balance conditions may be an exception — confirm with trial site)
• People who have a current or past history of genital herpes
• People who have had major surgery within 4 weeks before the first study day
• People who have received any blood products within 3 months before joining the trial
• People who have a significant current or past history of heart, liver, or kidney disease that has been medically unstable
• People who have a current or past neurological condition, including a history of seizures
• People who have taken part in another clinical trial or received an experimental drug within the two months before this trial

Important: Always verify eligibility with the trial site directly before applying.