Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a specific type of lung cancer (adenocarcinoma or large cell carcinoma) confirmed by a tissue or cell sample test.
• People whose lung cancer has been newly classified as stage IIIA, IIIB, or IIIC, and whose doctors consider them suitable for intensive chemotherapy combined with radiation treatment.
• People who have at least one tumour or lesion that is large enough to be measured precisely on a chest X-ray, CT scan, MRI, or physical exam (specific size thresholds apply — confirm with trial site).
• People who have not previously had radiation therapy that would overlap with the area being treated in this trial (prior radiation for early-stage lung cancer in a different area may be acceptable).
• People aged 18 or older.
• People who weigh more than 30 kg and have acceptable nutritional health as assessed by their treating doctor.
• People who are generally able to carry out daily activities with little limitation (this is measured using a standard scale — confirm with trial site).
• People whose blood test results meet specific requirements for white blood cell count, red blood cell levels, platelet count, liver function, and kidney function (specific values apply — confirm with trial site).
• People whose lungs are functioning at an acceptable level, as assessed by their treating doctor.
• People who are expected to live at least 12 months.
• Women who are past menopause, or women of childbearing age who have a negative pregnancy test before joining.
• People living with HIV may be eligible if their HIV is well controlled on stable medication, their virus levels have been undetectable in recent tests, and their immune cell counts meet specific thresholds — and they have not had a serious HIV-related infection recently (confirm with trial site).
• People with a history of hepatitis B who are on treatment and have undetectable virus levels in their blood.
• People with a history of hepatitis C who have been successfully treated and cured, or who are currently being treated and have undetectable virus levels.
• People with known heart conditions may be eligible if their heart function is assessed as class 2B or better on a standard medical scale (confirm with trial site).
• People who are willing and able to use reliable contraception during the trial and for 6 months after completing treatment (this applies to both men and women who could father or become pregnant).
• People who are willing and able to sign a consent form, or who have a legally authorised representative available to do so on their behalf.
• People who previously had early-stage lung cancer (stage I or II) treated with surgery or targeted radiation (in a non-overlapping area) may be eligible.

Who may not be able to join:

• People who have not yet recovered from significant side effects of previous cancer treatment (with the exception of hair loss).
• People who are currently taking part in another clinical trial involving an experimental treatment.
• People who have brain metastases (cancer that has spread to the brain), whether previously treated or currently active, as this trial is only for stage III disease.
• People whose lung cancer has a specific genetic change called an EGFR or ALK mutation.
• People who have had a serious allergic reaction to drugs that are chemically similar to those used in this trial.
• People with serious uncontrolled medical conditions, such as active infections, uncontrolled high blood pressure, unstable heart conditions, certain lung or digestive conditions, or mental health or social circumstances that could affect safe participation in the trial.
• People with mental health or personal circumstances that would make it difficult to follow the trial requirements.
• Women who are pregnant or breastfeeding.
• People with active or past autoimmune or inflammatory diseases (such as lupus, Crohn's disease, rheumatoid arthritis, or similar conditions) — though some exceptions apply, such as people with certain well-controlled or low-risk conditions like stable thyroid problems or vitiligo (confirm with trial site).
• People with active tuberculosis, active hepatitis B, or active hepatitis C infection (people with certain past or resolved infections may still be eligible — confirm with trial site).
• People who have received an organ transplant from another person.
• People who have had another type of cancer, unless it was treated with the intention of curing it, is not currently active, and carries a low risk of returning — some specific exceptions apply (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.