Phase 2 Melanoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to sign a consent form agreeing to take part in the study
• You have been diagnosed with a cancer that has been confirmed by a tissue sample (biopsy), and you are currently being treated with a single approved immunotherapy drug that works by blocking certain proteins (called PD-1 or PD-L1) — approved for use in Italy
• Your cancer has been assessed as stable (not growing significantly) based on official monitoring records
• You have at least 2 areas of cancer in your body that can be measured — one that can be tracked by standard scans, and one that is suitable for the type of radiation therapy used in this trial
• You are willing and able to attend all scheduled visits, tests, and follow all study requirements
• You are 18 years of age or older (there is no upper age limit)
• You are generally well enough to carry out some daily activities — not completely bedridden (this is measured by a standard scale called ECOG, score of 2 or lower)
• Your cancer can be measured using CT or MRI scans according to standard guidelines

Who may not be able to join:

• You are receiving chemotherapy combined with immunotherapy
• You are receiving a combination of two or more immunotherapy drugs at the same time
• You are receiving immunotherapy as part of another clinical trial
• You are receiving immunotherapy outside of its official approved use (such as through special access or compassionate use programmes)
• You have a very large amount of cancer spread in your body — more than 10 areas affected and/or the total size of tumours adds up to more than 19 cm
• The only area where your cancer has spread is the brain or spinal cord (central nervous system)
• You have a serious uncontrolled medical condition that the study doctor believes could put you at risk or affect the study results (confirm with trial site)
• You have an autoimmune disease, such as inflammatory bowel disease or a condition where the immune system attacks the body's own tissues
• The specific area of cancer chosen for radiation treatment in this trial has been treated with any type of radiation before
• You have had a severe immune-related side effect (grade 4 on a standard medical scale) at any point before joining the study
• You have had a serious immune-related side effect (grade 3 or higher) within the 3 weeks before the radiation treatment in this trial is due to start
• You have metal implants or another condition in your body that would prevent the medical team from taking the detailed scans needed to plan your radiation treatment
• There is a local condition — such as an active infection — in the area to be treated that would prevent the radiation therapy from being safely delivered (confirm with trial site)
• You are currently in prison or held in a facility against your will
• You are currently being detained under a legal order for treatment of a mental health or physical health condition

Important: Always verify eligibility with the trial site directly before applying.