Phase 3 Brain Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older.
• People who have a confirmed diagnosis of a specific type of brain tumour called glioblastoma (GBM), classified according to 2021 world health standards, including certain tumour features seen under a microscope or specific genetic markers found in the tumour.
• People whose general health and ability to carry out daily activities meets a minimum threshold, as measured by a standard medical scale called the Karnofsky Performance Status (70% or above).
• People whom the trial doctor believes have a life expectancy of at least 6 months.
• People who are able to have an MRI scan.
• People whose blood test results fall within acceptable ranges for immune cells, platelets, liver function, and kidney function (confirm with trial site for specific values).
• Women who could become pregnant must have a negative blood pregnancy test and be willing to use an acceptable form of contraception during the trial.
• Men who could father a child must be willing to use an acceptable form of contraception during the trial.
• People who are able to understand and willing to sign a consent form approved by an ethics review board (a legal representative may sign on someone's behalf if needed).

Who may not be able to join:

• People who have already started chemotherapy or radiation treatment for their GBM diagnosis.
• People whose brain tumour is a different type — such as an IDH mutant astrocytoma or any other non-GBM brain tumour — according to 2021 world health classification standards.
• People who plan to take part in another clinical trial at the same time.
• People who currently have an active infection that requires treatment.
• People whose scans show the tumour has spread to multiple areas of the brain or to the lining around the brain and spinal cord.
• People with a history of another cancer, unless they have been free of that cancer for at least 5 years. Certain skin cancers (basal cell or squamous cell) that have been adequately treated are generally acceptable regardless of when they occurred, as are localised prostate cancer or cervical pre-cancer treated with curative intent (confirm with trial site).
• People who have a known positive test for HIV, or who have an active hepatitis B or hepatitis C infection.
• People with another significant medical condition, disorder, or history that in the trial doctor's judgement could put them at risk or interfere with the trial (confirm with trial site).
• Women who are pregnant or currently breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.