Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with a specific type of head and neck cancer (squamous cell carcinoma of the oral cavity, oropharynx, larynx, or hypopharynx) that is at an advanced local stage (Stage III or IVA) and has not spread to other parts of the body, confirmed by tissue or cell testing
• People who have not previously received any treatment for this cancer, and who have at least one tumour that can be measured using standard imaging criteria
• People who are generally well enough to carry out light activity and care for themselves, as rated by a standard medical scale (ECOG score of 0 or 1)
• Adults aged 18 to 70 years at the time of signing the consent form
• People whose liver, kidney, heart, and blood cell levels fall within the ranges required by the trial, as shown by blood tests
• Women who could become pregnant must have a negative pregnancy test within 28 days before joining, with an additional urine test required if the original test was done more than 7 days before the first dose
• People who are willing to participate fully and follow the trial requirements

Who may not be able to join:

• People with an active, known, or suspected autoimmune disease, Type 1 diabetes, hypothyroidism needing hormone replacement, or skin conditions requiring systemic (whole-body) treatment
• People currently taking steroid medication at a dose higher than 10 mg per day of prednisone (or equivalent), or any other immune-suppressing medication, within 14 days before joining
• People with active Hepatitis B (with specific virus levels above a set threshold), active Hepatitis C, or HIV
• People with an active tuberculosis (TB) lung infection, as determined by chest imaging, sputum testing, and physical examination
• People with serious heart conditions, including heart failure, difficult-to-control dangerous heart rhythm problems, unstable chest pain, recent heart attack, or high blood pressure that cannot be managed
• Women who are pregnant or currently breastfeeding
• People who are able to have children but are unwilling to use effective contraception during the trial
• People who are currently taking part in another clinical trial or have recently received an experimental treatment or used an experimental medical device
• People who have had another known invasive cancer or a cancer that cannot be surgically removed
• People who have received a live vaccine within 30 days before the planned start of the trial treatment
• People whose medical history, current health conditions, or test results might affect the trial results or make participation not in their best interest, as judged by the treating doctor

Important: Always verify eligibility with the trial site directly before applying.