Phase 1 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older and have been diagnosed (confirmed by tissue testing) with an advanced or spreading solid tumor, specifically one of these cancer types: prostate cancer that no longer responds to hormone treatment (including a specific subtype called neuroendocrine prostate cancer), hormone receptor-positive/HER2-negative breast cancer, colorectal cancer, cervical cancer, non-small-cell lung cancer, or recurring glioblastoma (brain tumor)
• You are able to understand and sign a consent form agreeing to take part in the study
• Your cancer has continued to grow or spread after trying at least 2 different treatments (this does not apply to recurring glioblastoma)
• If you have prostate cancer: you have had surgical or ongoing hormone treatment to lower testosterone, and your testosterone levels are very low (below a specific threshold)
• At least one of your tumors can be measured on a scan, and it shows uptake of a special imaging substance used in this trial (not required for glioblastoma)
• If you have prostate cancer without measurable soft tissue tumors, uptake of the imaging substance in bone tumors is acceptable (confirm with trial site)
• Your general health and ability to carry out daily activities meets a specific minimum level on a standard scale (rated 0 or 1, meaning fully active or able to do light activity); a score of 2 may be considered on a case-by-case basis
• Your blood, liver, and kidney function results are within acceptable ranges, including healthy enough levels of white blood cells, infection-fighting cells, platelets, haemoglobin, liver enzymes, bilirubin, kidney function, and pancreatic enzymes
• If you could become pregnant, or if your partner could become pregnant, you are willing to use reliable contraception or abstinence during the study and for a set period after your last treatment dose
• If you have recurring glioblastoma: your tumor has come back for the first or second time after standard treatment including radiation therapy, and at least 12 weeks have passed since completing that radiation; if you had surgery for the recurrence, it was completed at least 4 weeks before starting this trial's treatment with no complications
• If you have recurring glioblastoma: your tumor shows uptake of the imaging substance on a special scan, and shows a specific type of enhancement on an MRI scan at the time the recurrence was diagnosed

Who may not be able to join:

• The official criteria do not list specific exclusion criteria in the text provided; please confirm all exclusion criteria directly with the trial site (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.