Phase 3 Interstitial Lung Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 70 years old (both ages included), and any gender may apply
• You have been officially diagnosed with silicosis or coal worker's pneumoconiosis according to Chinese occupational disease diagnostic standards
• Your lung breathing capacity (FVC) is between 40% and 80% of what would be expected for a healthy person your age
• Your lungs' ability to transfer oxygen into the blood (DLCO) is between 30% and 80% of the expected normal level
• A special type of chest scan (HRCT) shows widespread changes to the tissue throughout your lungs
• You are willing to take part, can follow the study instructions, and are able to read and sign a consent form

Who may not be able to join:

• You have had a lung wash-out procedure (lung lavage) in the last 3 months, or plan to have one during the trial
• Your liver function blood test results are significantly higher than normal (confirm with trial site)
• Your kidney function is significantly reduced (confirm with trial site)
• You have had an infection or high fever in the past 4 weeks, such as chest infection, pneumonia, sinus infection, urinary tract infection, or a skin infection
• You currently have tuberculosis or lung cancer
• You have serious high blood pressure in the lungs or severe right-sided heart failure that your doctor feels makes participation unsafe
• You have had serious heart or blood pressure problems, including very high uncontrolled blood pressure in the last 6 weeks, a heart attack in the last 6 months, or unstable chest pain in the last 6 months
• Your blood clotting test results are significantly above normal (confirm with trial site)
• You have difficulty swallowing, problems absorbing food, or need to be fed through a tube or drip
• You have an active stomach ulcer
• You have had a blood clot, stroke, or mini-stroke in the last 12 months
• You are currently taking certain immune-suppressing or cell-affecting medications, such as methotrexate, cyclosporine, or TNF-alpha inhibitors (confirm with trial site for full list)
• You have taken certain specific lung or related medications within the last month before joining, including nintedanib or high-dose acetylcysteine (confirm with trial site for full list)
• You have previously taken medications that can cause lung scarring (such as amiodarone), or have been exposed to asbestos, beryllium, or radiation
• You are allergic to the study drug or any of its ingredients (including lactose)
• Your doctor believes you have less than 2.5 years to live due to another medical condition
• You have a major operation planned during the time you would be on the trial
• You are pregnant, breastfeeding, or planning to become pregnant during the trial
• You are a woman who could become pregnant but are unwilling or unable to use reliable contraception from 28 days before to 3 months after taking the study drug
• Your doctor believes you have a problem with alcohol or drug misuse
• You have a mental illness
• You have taken part in another clinical drug trial in the last 3 months
• For any other reason, the trial doctor does not think it is safe or suitable for you to participate

Important: Always verify eligibility with the trial site directly before applying.