Phase 3 OCD Trial, Recruiting NCT05331937 Sponsor: Amsterdam UMC, location VUmc Condition: OCD
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Phase 3 OCD Trial, Recruiting

NCT05331937
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have been diagnosed with OCD as your main current condition
  • You are 18 years of age or older
  • Your OCD symptoms score 16 or higher on a standard OCD severity scale called the YBOCS (confirm with trial site)
  • You have not responded well enough to a standard OCD therapy called exposure and response prevention (ERP), or you had to stop ERP because anxiety or avoidance was too overwhelming
  • You have other conditions alongside OCD — such as depression, anxiety disorders, ADHD, tic disorders, eating disorders, personality disorders, or autism spectrum disorder (when it is not your main diagnosis) — and these are still permitted
  • You are willing and committed to taking part in intensive therapy sessions, including practice at home on your own
  • You are either not taking any psychiatric medication, or you have been on a stable dose of an antidepressant (such as an SSRI, SNRI, or clomipramine) or certain other psychiatric medications for at least 8 weeks
  • You are able to attend treatment sessions 4 days per week for 5 to 7 weeks at one of the participating sites near your home or work
  • You are able to attend a brain scan (MRI) session at one of the academic trial sites near your home or work
  • You are able to give informed consent to take part in the trial

Who may not be able to join:

  • Your main OCD symptom is hoarding
  • You currently have a diagnosis of a psychotic disorder, bipolar disorder, autism spectrum disorder (when it is your main diagnosis), or a substance use disorder
  • You are currently having active thoughts of suicide with intent to act on them
  • You regularly use benzodiazepine medications (such as diazepam or lorazepam)
  • You have a cochlear implant (a device implanted in the ear)
  • You have epilepsy, or have had it in the past
  • You are currently pregnant
  • You have severe claustrophobia or have metal objects in or on your body that would prevent you from having an MRI scan
  • An MRI scan has shown a growth or mass in your brain
  • You have previously received a treatment called rTMS (a type of brain stimulation)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: +31-20-4444444

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
Amsterdam UMC, location VUmc
Registry
ClinicalTrials.gov
Start date
16 May 2022
Est. completion
1 December 2027

Where this trial is recruiting

🇳🇱 Netherlands

Primary endpoints

Y-BOCS

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov