Early Phase 1 Lung Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You (or your legal guardian) must be willing and able to sign a written consent form before any screening begins
• You are between 18 and 75 years old and have been diagnosed with advanced lung cancer or triple-negative breast cancer (including cases where targeted therapy treatments have stopped working), confirmed by a tissue or cell sample
• A tumor test done within the last 3 months has shown that your cancer cells test positive for certain proteins called EGFR and B7H3
• You have at least one tumor that can be measured on a scan, with scan results available from within the last month
• Your doctors expect you to live for at least 12 weeks
• You are generally able to carry out light activity and care for yourself (a standard medical fitness score of 0 or 1)
• Your liver and kidneys are working well enough, based on recent blood tests showing results within acceptable ranges
• Your heart is pumping blood effectively, with a heart function score of at least 50% on a heart scan
• Your blood counts are at acceptable levels (you may qualify even if you needed a blood transfusion to reach these levels)
• If you are a woman who could become pregnant, or a man, you must agree to use effective contraception for at least 52 weeks after treatment, and until two consecutive tests confirm the treatment cells are no longer in your body

Who may not be able to join:

• You have poorly controlled high blood pressure, serious heart problems (such as a recent heart attack within the last 6 months, uncontrolled irregular heartbeat, unstable chest pain, or significant heart failure)
• You have severe liver or kidney problems, or difficulties with consciousness or mental awareness
• You have received cancer chemotherapy (other than a specific preparatory treatment) within the 14 days before the cell infusion
• You have taken part in another clinical trial or received another experimental drug within the 14 days before infusion
• You have had radiotherapy or certain targeted cancer drugs (TKIs) within the 2 weeks before infusion
• You have active Hepatitis B (confirm with trial site for specific test levels)
• You test positive for HIV, Hepatitis C, or syphilis
• You have active tuberculosis, confirmed by certain tests
• You have a lung condition involving inflammation or scarring of lung tissue (interstitial lung disease or pneumonia)
• You have a serious, uncontrolled bacterial, viral, or fungal infection (for example, a positive blood infection test within 72 hours of the planned infusion)
• You have a tumour in or spreading to the brain that is not stable or is causing symptoms, or a tumour that has spread to the sac around the heart with a large build-up of fluid (confirm with trial site for details on exceptions)
• You currently have, or have previously had, a second different type of cancer — with some exceptions, such as certain fully treated skin cancers, early-stage cervical or breast cancer with no recurrence for at least 3 years, or a previous cancer that was fully removed and has been in complete remission for 5 or more years
• You are currently pregnant or breastfeeding
• You have a history of, or currently have, a type of cancer affecting T-cells
• You have an active autoimmune or inflammatory condition affecting the nervous system (such as Guillain-Barré syndrome or ALS/motor neurone disease)
• The trial doctor believes, for any other reason, that joining the trial would not be right for you

Important: Always verify eligibility with the trial site directly before applying.