Obesity Trial, Recruiting NCT05356000 Sponsor: University of Chicago Condition: Obesity
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Obesity Trial, Recruiting

NCT05356000
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

People who have had Roux-en-Y gastric bypass surgery:

  • Adults aged 18 to 70 who have previously had a type of weight-loss surgery called Roux-en-Y gastric bypass
  • People who have had at least one calcium-based kidney stone after that surgery
  • People whose urine oxalate levels (a substance measured in urine) are higher than the normal range before the study begins

People who are living with obesity but have not had gastric bypass surgery:

  • Adults aged 18 to 70 with a body mass index (a measure of body weight relative to height) of 30 or above
  • People who have had at least one calcium-based kidney stone
  • People whose urine oxalate levels are higher than the normal range before the study begins

People who are not living with obesity and have not had gastric bypass surgery:

  • Adults aged 18 to 70 with a body mass index between 18.5 and 29.9
  • People who have had at least one calcium-based kidney stone

Who may not be able to join:

People who have had Roux-en-Y gastric bypass surgery:

  • People who have had part or all of their colon (large intestine) removed
  • People who have had a type of bowel surgery called a duodenal switch
  • People who have had a type of bowel surgery called ileal-jejunal bypass
  • People whose kidney stones have been mainly made of uric acid, cysteine, or struvite (rather than calcium)

People who are living with or without obesity but have not had gastric bypass surgery:

  • People who have had any bowel surgery
  • People who have had part or all of their colon removed
  • People who have been diagnosed with an inflammatory bowel disease such as Crohn's disease or Ulcerative Colitis
  • People whose kidney stones have been mainly made of uric acid, cysteine, or struvite (rather than calcium)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Phone: 773-702-1000

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

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Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
25 January 2023
Est. completion
2 June 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change in 24-hour urine oxalate from baseline to after 5 days on low oxalate diet (2 days on participant managed, 3 days on clinical research center prepared diet of 50mg/day); Percent absorption of 13C2-oxalate from pre-load baseline (time 0) to 2, 4-, 6-, and 24-hour time points; Change in urine 13C2-oxalate from pre-load baseline (time 0) to 2, 4-, 6-, and 24-hour time points; Percent absorption total urine oxalate from pre-load baseline (time 0) to 2, 4-, 6-, and 24-hour time points; Percent absorption of sucralose from pre-load baseline (time 0) to 2, 4-, 6-, and 24-hour time points; Chan...

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov