Phase 2 Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to give written consent before any assessments are done
• People who have been diagnosed with relapsing remitting multiple sclerosis and have had the condition for less than 15 years
• People aged 18 to 55 years old (inclusive)
• Women who meet at least one of the following conditions around pregnancy prevention: have been through menopause for at least one year; have had a surgical procedure that prevents pregnancy (such as hysterectomy, removal of both ovaries, or tubal ligation); have a male partner who has had a vasectomy; are using a highly effective form of birth control for the full duration of the trial; are not currently in a heterosexual relationship but agree to use highly effective birth control if that changes; or are not sexually active in a way that could lead to pregnancy as part of their regular lifestyle (note: calendar or ovulation-tracking methods alone are not accepted)

Who may not be able to join:

• People whose most recent MRI shows significant brain shrinkage for their age, as assessed by a specialist radiologist or the trial doctor
• People who have a new lesion (area of damage) showing on an MRI taken within the last 3 months
• People who have had an allergic reaction to clemastine, similar antihistamine medicines, or any ingredients in the trial medication
• People who have been treated with corticosteroids (a type of anti-inflammatory medicine) in the 30 days before screening
• People who score 4.5 or higher on a standard disability scale used to measure MS progression (confirm with trial site)
• People with a history of a significant heart conduction problem (an issue with the electrical signals that control the heartbeat)
• People with a history of cancer
• People who have had thoughts of suicide or suicidal behaviour in the 6 months before the start of the trial
• People who are pregnant, breastfeeding, or planning to become pregnant
• People already taking part in another research study at the same time, unless the trial site has given prior approval
• People currently using any other treatment intended to repair the myelin (protective coating on nerves), as decided by the trial doctor
• People who have previously received total lymphoid irradiation, or T cell or T cell receptor vaccination
• People who have previously been treated with alemtuzumab, mitoxantrone, or cyclophosphamide (specific medicines used in some MS or cancer treatments)
• People whose recent blood test results (taken within 72 hours) show kidney or liver function outside of acceptable ranges (confirm specific values with trial site)
• People with a history of drug or alcohol misuse within the past year
• People with untreated vitamin B12 deficiency or untreated underactive thyroid, as confirmed by blood tests
• People with other significant ongoing health conditions that, in the trial doctor's judgement, could affect the safety of participation or the interpretation of results
• People who are unable to have an MRI scan, including those with severe claustrophobia
• People who have dental braces or any permanent or non-removable metal in the jaw or face

Important: Always verify eligibility with the trial site directly before applying.