Sickle Cell Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For young people with Sickle Cell Disease (SCD):

• People between Tanner stages 1–5 (roughly ages 10–17) with a diagnosis of sickle cell disease in any relevant form
• People considered to be in relatively good health for someone with SCD, with no SCD complications that a doctor considers would make participation unsafe
• People with no other illness or disability that would prevent participation in physical activity
• People whose doctor has given permission to take part in a cardiopulmonary exercise test (a supervised breathing and fitness test)
• People whose body weight falls within the typical range for their age and condition

For young people with Cystic Fibrosis (CF):

• People between Tanner stages 1–5 (roughly ages 10–17) with a confirmed CF diagnosis, either through two CF-related gene mutations and/or a sweat chloride test result above 60 mmol/l
• People considered to be in relatively good health for someone with CF, with no CF complications — such as severe lung bleeding or significant lung blood pressure problems — that a doctor considers would make participation unsafe
• People whose body weight falls within the typical range for their age and condition
• People with no other illness or disability that would prevent participation in physical activity

For healthy comparison participants:

• People between Tanner stages 1–5 (roughly ages 10–17) who are considered to be in good health following a health check by a primary care provider or trial staff
• People whose body weight and physical activity levels fall within the typical range for their age
• People with no illness or disability that would prevent participation in physical activity

For participants who have had a COVID-19 (SARS-CoV-2) infection:

• People between Tanner stages 1–5 (roughly ages 10–17) with a documented COVID-19 infection
• People whose primary care provider or trial medical staff consider to be capable of doing exercise

Who may not be able to join:

For young people with Sickle Cell Disease:

• People currently receiving regular monthly blood transfusions
• People with other conditions that prevent exercise, such as a neurological movement disorder, heart disease, or any similar condition
• People currently being treated for substance or alcohol misuse

For young people with Cystic Fibrosis:

• People whose lung function (FEV1) is below 40% of the expected level for their age and size
• People with a current infection with specific bacteria — Burkholderia cenocepacia or Mycobacterium abscessus (confirm with trial site)
• People with other conditions that prevent exercise, such as a neurological movement disorder, heart disease, or any similar condition
• People currently being treated for substance or alcohol misuse

For healthy comparison participants:

• People currently being treated for substance or alcohol misuse, or who are taking ongoing regular medications
• People considered unsuitable for exercise by trial staff

For COVID-19 comparison participants:

• People currently being treated for substance or alcohol misuse, or who are taking ongoing regular medications
• People considered unsuitable for exercise by trial staff

Important: Always verify eligibility with the trial site directly before applying.