Phase 3 Chronic Kidney Disease Trial, Recruiting NCT05410275 Sponsor: University Hospital, Tours Condition: Chronic Kidney Disease
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Phase 3 Chronic Kidney Disease Trial, Recruiting

NCT05410275
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged 18 or older
  • People who have been receiving regular kidney dialysis (hemodialysis) for at least 3 months
  • People who are covered by a social security or health insurance plan
  • People who have read, understood, and signed a consent form agreeing to take part

Who may not be able to join:

  • People who need to take long-term blood-thinning (anticoagulant) medication for conditions such as an irregular heartbeat, blood clots, mechanical heart valves, or blood clots inside the heart
  • People taking two different blood-thinning/anti-clotting medications at the same time, or taking aspirin at a dose higher than 160 mg per day
  • People with poorly controlled high blood pressure (above 180/110 mmHg)
  • People who had a stroke caused by a blocked blood vessel in the 30 days before joining
  • People with a history of a serious, unexplained bleeding episode that required a hospital stay or a blood transfusion, at any point in their life
  • People who had surgery in the 30 days before joining
  • People with an additional condition that significantly raises their risk of bleeding, such as a known blood clotting disorder, a low platelet count (below 100G/L), an active cancer affecting the digestive or urinary system, or a known abnormal blood vessel in the brain
  • People with severe liver disease
  • People taking certain strong medications that can interfere with how the body processes the study drug, including rifampin, St. John's Wort, carbamazepine, phenytoin, or phenobarbital
  • People who are considered unlikely to follow the trial's requirements as directed
  • People who are pregnant or breastfeeding, or people of childbearing age who are not using an effective form of contraception
  • People who have a medical condition that makes blood-thinning treatment unsuitable, such as anti-phospholipid antibody syndrome
  • People with a known allergy to rivaroxaban or any of its ingredients, including lactose monohydrate
  • People who are under legal guardianship or conservatorship
  • People who are currently taking part in another clinical study, or who finished another clinical study less than 30 days before joining this one

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 12 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Fabrice IVANES, MD-PhD, University Hospital of TOURS

Phone: +33247473663

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
University Hospital, Tours
Registry
ClinicalTrials.gov
Start date
8 January 2025
Est. completion
30 January 2027

Where this trial is recruiting

🇫🇷 France

Primary endpoints

Pharmacodynamics of 3 reduced dose regimen of rivaroxaban (5 mg/day, 10 mg/day, or 15 mg/day); Pharmacokinetics of 3 reduced dose regimen of rivaroxaban (5 mg/day, 10 mg/day, or 15 mg/day)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 12 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov