Phase 2 Non-Alcoholic Fatty Liver Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old (male or female) and have had a liver transplant for any reason (such as fatty liver disease, hepatitis C, alcohol-related liver disease, or autoimmune hepatitis)
• Your liver transplant surgery took place between 8 and 24 weeks before joining the study
• You have been diagnosed with diabetes, pre-diabetes, or have a fasting blood sugar level above 125 mg/dL
• You are able to understand and sign a consent form agreeing to take part in the study
• You have already been discharged from the hospital after your liver transplant
• You are able to eat and tolerate a normal diet
• Your transplanted liver is working normally, as confirmed by your liver doctor or surgeon
• You are on a stable anti-rejection medication routine as set by Virginia Commonwealth University's transplant program (typically two specific types of anti-rejection drugs)
• If you are a woman who could become pregnant, you must not currently be pregnant (confirmed by a negative pregnancy test), not be breastfeeding, and must be using an accepted form of birth control, or be surgically sterile or post-menopausal

Who may not be able to join:

• Your Body Mass Index (BMI — a measure of body weight relative to height) is 27 or below
• Your kidneys are not filtering blood well enough (confirm with trial site)
• You have Type 1 autoimmune diabetes, confirmed by a specific blood test or a history of a serious diabetes-related emergency called ketoacidosis
• You have a history of gastroparesis (a condition where the stomach empties food too slowly)
• You or a close family member have had a specific type of thyroid cancer (medullary thyroid cancer) or a related hormonal condition called Multiple Endocrine Neoplasia type 2
• You have a history of pancreatitis (inflammation of the pancreas)
• You have had an active cancer since your liver transplant, with the exception of certain common, less dangerous skin cancers
• You have a history of uncontrolled or unstable damage to the eyes caused by diabetes
• You are currently experiencing rejection of your transplanted liver
• You have a blockage or clot in the main artery supplying your transplanted liver
• You have a history of not following your medical treatment plan as directed
• You are currently taking a type of diabetes medication known as a GLP-1 receptor agonist or an SGLT-2 inhibitor at the time of screening (confirm with trial site)
• You have had an allergic reaction to semaglutide or any of its ingredients in the past
• You are pregnant, breastfeeding, planning to become pregnant during the study, or not using adequate contraception

Important: Always verify eligibility with the trial site directly before applying.