Phase 3 Sickle Cell Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have sickle cell disease (SCD)
• Your hemoglobin (a measure of red blood cells) levels are considered stable by your doctor
• If you are taking hydroxyurea and/or L-glutamine, your dose has been unchanged for at least 90 days before joining and is not expected to change during the study
• You are between 12 and 65 years old (for the main study portion called Part B)
• You have had 2 or more, but no more than 10, pain crises (called vaso-occlusive crises, or VOCs) in the past 12 months (for Part B)
• You have already completed Part B of the study (to be eligible for the follow-on open-label extension portion)

Who may not be able to join:

• You have had more than 10 pain crises (VOCs) in the past 12 months
• You are currently pregnant or breastfeeding
• You receive regular red blood cell transfusions, or you have had a red blood cell transfusion for any reason in the past 90 days
• You were hospitalized for a sickle cell crisis or related painful event within the past 14 days before signing up, or at any point during the screening period

Important: Always verify eligibility with the trial site directly before applying.