Phase 2 Thyroid Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• (Phase 1 only) You have been diagnosed with a solid tumor cancer that has spread and cannot be removed by surgery.
• (Phase 2 only) Your tumor has been tested and found to have a specific gene change called a RET rearrangement, fusion, or certain RET mutation.
• You are able to carry out basic daily activities, ranging from fully active to capable of self-care but unable to work (confirm with trial site).
• Your cancer can be measured or tracked using standard imaging scans.
• Your blood, liver, and kidney functions are at acceptable levels.
• You are expected to live for at least 12 weeks.
• If you are a woman who could become pregnant, you have a negative pregnancy test (urine or blood).
• You are willing to provide a tumor tissue sample, either from a previous biopsy or a new one.

Who may not be able to join:

• Your cancer is primarily driven by a gene change other than RET.
• You have received certain chemotherapy drugs (nitrosourea, anthracyclines, or mitomycin) within the last 6 weeks.
• You have had chemotherapy, immunotherapy, radiation therapy, or major surgery within the past 4 weeks (or longer, depending on the specific treatment).
• You have received a large amount of radiation to your bone marrow or widespread radiation therapy within the past 4 weeks (or 2 weeks for palliative/pain-relief radiation).
• You have taken traditional Chinese herbal medicine for cancer treatment within the past week.
• You have received a live vaccine within the past 4 weeks.
• You are currently in another clinical trial or have received an experimental treatment within the past 4 weeks (or longer, depending on the treatment).
• You still have significant side effects from a previous cancer treatment that have not resolved.
• You have cancer that has spread to the brain or spinal cord and is causing worsening neurological symptoms.
• You have been diagnosed with another type of cancer within the past 5 years.
• You have a history of serious heart disease.
• You have active hepatitis B, active hepatitis C, or HIV.
• You have active lung inflammation or lung disease that requires treatment.
• You have fluid build-up around your lungs, abdomen, or heart that is not well controlled.
• You have a condition that seriously affects your ability to swallow or absorb medication through your digestive system.
• You have taken certain strong medications that affect how the body processes drugs (strong CYP3A inhibitors or inducers) within the past 2 weeks, or proton pump inhibitors (such as omeprazole) within the past week (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.