Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to sign a consent form before any study procedures begin
• You are between 18 and 75 years old
• You have been diagnosed with non-small cell lung cancer (NSCLC) that has been confirmed by a tissue or cell sample, and the cancer is at a locally advanced stage (Stage III)
• You have not previously received chemotherapy, radiotherapy, surgery, targeted therapy, or immunotherapy for this cancer
• A recent sample of your tumour may be requested, if it is safe and technically possible to obtain one
• Your doctors expect you to live for at least 12 weeks
• You are generally well enough to carry out light activity (your doctor will assess this using a standard scale)
• If you are a woman who has not gone through menopause, you must have a negative pregnancy test within 14 days before starting the study drug
• You are not currently breastfeeding
• Your lung breathing test shows a strong enough airflow (confirm with trial site)
• Your blood tests show that your white blood cells, platelets, and red blood cells are at acceptable levels
• Your kidneys and liver are functioning well enough, based on blood test results

Who may not be able to join:

• You are already taking part in another clinical trial that involves a treatment or intervention
• Your lung cancer has features of both small cell and non-small cell types
• You have taken immune-suppressing medicines in the 28 days before starting the study drug (with some exceptions for low-dose or inhaled steroids — confirm with trial site)
• You have previously been treated with a type of immunotherapy that targets PD-1 or PD-L1 proteins
• You have had major surgery within the 4 weeks before joining the study
• You have or have had an autoimmune disease (where the immune system attacks the body) within the last 2 years
• You have or have had inflammatory bowel disease, such as Crohn's disease or ulcerative colitis
• You have a condition where your immune system does not work properly from birth
• You have had an organ transplant that requires you to take immune-suppressing medicines
• Your tumour has completely surrounded or grown into major blood vessels near the heart or lungs
• You have a tendency to bleed easily or a blood clotting disorder
• You have had a serious heart or blood pressure crisis, stroke, or significant heart failure within the last 6 months
• Your blood pressure is not well controlled (consistently above 150/100 mmHg)
• You have had major surgery within the last 28 days, or minor surgery or a needle biopsy within the last 48 hours
• Your urine tests show a high level of protein in your urine
• Your heart's electrical activity (measured by an ECG) shows a certain abnormality (confirm with trial site)
• You have an uncontrolled serious illness, active infection, unstable heart condition, active stomach ulcer, or a mental health condition that might affect your ability to follow the study requirements
• You have a known history of hepatitis B, hepatitis C, or HIV
• You have a known history of tuberculosis
• You have received a live vaccine within 30 days before joining the study or starting the study drug
• You have been diagnosed with another cancer within the last 5 years, with some exceptions such as certain treated skin cancers or cervical conditions (confirm with trial site)
• You are pregnant or could become pregnant and are not using an effective method of contraception, or you are a male patient of reproductive age not using effective contraception
• Your doctor feels there is any other reason you should not take part in this study

Important: Always verify eligibility with the trial site directly before applying.