Phase 1 Bladder Cancer Trial, Recruiting NCT05483868 Sponsor: Aura Biosciences Condition: Bladder Cancer
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Phase 1 Bladder Cancer Trial, Recruiting

NCT05483868
Recruiting Phase 1 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed with a type of bladder cancer called non-muscle-invasive bladder cancer (NMIBC), confirmed by a tissue sample taken during a procedure or biopsy, with specific requirements depending on which group (cohort) of the trial applies to them (confirm with trial site)
  • For certain groups, people with a low-grade, intermediate-risk form of NMIBC — for example, cancer found in multiple spots, a single tumour larger than 3 cm, or low-grade cancer that has come back within one year
  • For other groups, people with a high-risk form of NMIBC, which may include certain tumour types with or without a related condition called CIS (carcinoma in situ)
  • People who have never received a treatment called BCG, or who have received it previously but did not respond fully or could not tolerate it — as long as they do not meet the definition of "BCG-refractory" (confirm with trial site for the specific definition)
  • People who have no current or past spread of bladder cancer to other parts of the body
  • People whose bone marrow, kidneys, and liver are functioning well enough to meet the trial's health requirements

Who may not be able to join:

  • People who have another cancer that currently requires active treatment, unless the trial's medical team reviews the situation and decides it is appropriate
  • People who have taken an experimental drug or used an experimental medical device within the past 30 days (or longer, depending on the drug), or who are already taking part in another experimental trial
  • People who currently have an active bacterial, fungal, or viral infection, or who are still taking antibiotic or antiviral medicines
  • People who have an active autoimmune disease, a chronic inflammatory condition, or a condition such as an organ transplant or bone marrow transplant that requires ongoing use of medicines that suppress the immune system, including steroids
  • People who have chronic active hepatitis B, hepatitis C, or HIV
  • People whose NMIBC is classified as "BCG-refractory," meaning the cancer continued or worsened despite a full course of BCG treatment (confirm with trial site for the exact definition)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
Phase 1: approximately ~10% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Medical Monitor, Aura Biosciences

Phone: 617-500-8864

Australian sites

Westmead Private Hospital, Westmead, New South Wales
+61 4 1943 4636
Austin Health, Heidelberg, Victoria
+61 3 9496 4915
Warringal Private Hospital, Heidelberg, Victoria
+61 456 359 569
Penninsula Private Hospital, Langwarrin, Victoria
+61 3 9788 3647
The Royal Melbourne Hospital, Parkville, Victoria
+61 3 9342 7294
Hollywood Private Hospital, Nedlands, Western Australia
+61 8 9346 6022

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 1
Sponsor
Aura Biosciences
Registry
ClinicalTrials.gov
Start date
26 September 2022
Est. completion
1 March 2027

Where this trial is recruiting

🇦🇺 Australia 🇺🇸 United States

6 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Safety of AU-011: Incidences of SAEs and DLTs

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov