Phase 2 Head and Neck Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with HPV-related squamous cell cancer of the oropharynx (such as the tonsil, base of tongue, or oropharyngeal walls), confirmed by a tissue or cell sample from a biopsy or surgery
- Cancer of unknown origin in the neck may also qualify, if a lymph node biopsy has been done or the trial leaders approve (confirm with trial site)
- You must have visible or measurable cancer present at the tumor site or nearby lymph nodes
- There is no sign that the cancer has spread to distant parts of the body, based on a PET/CT scan
- You have had a CT or MRI scan of the neck with and without contrast dye
- You are generally well enough to carry out basic daily activities (your doctor can assess this using standard performance scales)
- You are 18 years of age or older (note: those over 70 may only be eligible for a specific group within the trial)
- Your blood counts are at acceptable levels, tested within the last 30 days (enough white blood cells, neutrophils, platelets, and hemoglobin)
- Your kidneys are working well enough, based on a blood test taken within the last 30 days
- Your liver is working well enough, based on blood tests taken within the last 30 days
- If you are a woman who could become pregnant, you have had a negative pregnancy test within the last 14 days
- You are willing and able to sign a consent form agreeing to take part in the study
- You are able to have MRI scans, unless there is a strong medical reason you cannot (such as having a pacemaker), or the trial leaders approve an exception
Who may not be able to join:
- You have previously had radiation therapy to the head or neck area
- You currently have another active cancer outside of the oropharynx (though exceptions may be possible with trial leader approval)
- You have had a different invasive cancer in the past, unless you have been cancer-free for at least 3 years, or the previous cancer had a very high cure rate (confirm with trial site)
- You have previously received chemotherapy specifically for this oropharyngeal cancer (prior chemotherapy for a completely different cancer is acceptable)
- You have serious unstable heart problems or heart failure that required a hospital stay in the last 6 months
- You had a serious heart attack within the last 6 months
- You currently have a serious bacterial or fungal infection being treated with intravenous antibiotics
- You have had a serious flare-up of a lung condition, or another breathing problem, that required hospitalisation or would prevent you from receiving treatment within the last 30 days
- You have serious liver failure causing yellowing of the skin or eyes, or problems with blood clotting
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Nancy Lee, MD, Memorial Sloan Kettering Cancer Center
Phone: 212-639-3341
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Number of participants with any locoregional recurrences
Can't join this trial?
Data last synced from ClinicalTrials.gov: 14 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.