Phase 2 Non-Alcoholic Fatty Liver Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older (or the legal age of adulthood in their country)
• People who have been diagnosed with a liver condition called MASH (a type of fatty liver disease) with a moderate level of liver scarring, classified as stage 2 or 3
• People whose liver disease activity score (called a NAS score) is 3 or higher, as measured by a specific method set out in the trial rules
• People who meet certain genetic criteria set out in the trial rules (confirm with trial site)
• People who have had a specific liver assessment test called a FAST score (using a FibroScan® device combined with a blood test) either at the start of the trial or within about 12 weeks before joining

Who may not be able to join:

• People who have another known long-term liver disease, beyond the condition being studied
• People who have a known history of alcohol misuse or other substance misuse within the past year, or at any point during the screening period
• People who have a history of Type 1 diabetes
• People who have had weight-loss (bariatric) surgery within approximately the last 5 years, or who are planning to have it during the trial
• People who have previously taken an experimental drug that targets specific proteins called HSD17B13 or PNPLA3 (for example, ALN-HSD, ARO-HSD, ALN-PNP, or AZD2693)

Important: Always verify eligibility with the trial site directly before applying.