Phase 3 Muscular Dystrophy Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with Myotonic Dystrophy Type 1 (DM1), confirmed by a genetic test
- You are between 18 and 70 years old
- You are able to walk, even if you need a walking stick for support
- Your level of muscle involvement falls within a specific range on a disease severity scale called MIRS (score 3 or 4) — (confirm with trial site)
- If you are a woman who could become pregnant, you are using effective contraception throughout the study
- You are able to understand and agree to take part in the study yourself
- You have read and signed the study's consent form
- You are covered by a social security or health insurance system
Who may not be able to join:
- Women who are pregnant or currently breastfeeding
- Men who are planning to have a child during the study period
- Anyone who has an allergy or sensitivity to Metformin or any of its ingredients
- People who need a tracheotomy (a breathing tube in the throat) or who rely on a breathing machine for more than 12 hours a day, or whose breathing is not adequately supported by a machine
- People whose kidneys are not filtering blood well enough (confirmed by a blood test) — (confirm with trial site)
- People with certain heart conditions, including poor heart pumping ability, abnormal electrical activity in the heart without a pacemaker or defibrillator, certain types of heart rhythm problems, or a dangerous fast heart rhythm
- People who have a sudden or serious illness that reduces oxygen supply to their body's tissues
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Pascal LAFORÊT, MD, PhD, Neurology Department, Raymond Poincaré Hospital, APHP
Phone: +33 (0)1 47 10 77 36
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change of muscle function
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.