Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 70 years old
• You have been diagnosed with breast cancer that has come back or spread to other parts of the body, and your cancer has tested negative for HER2 (a specific protein)
• You have at least one measurable area of cancer in the brain that is 10mm or longer
• You are fairly active and able to care for yourself (your doctor will assess this using a standard scale)
• You have brain tumors that have either never been treated, or were treated before but are not currently getting worse and do not need urgent treatment right now
• Any side effects from previous cancer treatments have mostly cleared up before joining the trial
• Your blood cell counts (white blood cells, platelets, and red blood cells) are within acceptable levels based on a blood test taken within 1 week before joining
• Your liver and kidney function tests are within acceptable levels taken within 1 week before joining
• If you are able to have children, you agree to use effective birth control during the study and for 90 days after the last dose, and you have a negative pregnancy test before starting
• You are expected to live for more than 12 weeks
• You are able to attend appointments and follow the treatment plan

Who may not be able to join:

• Your breast cancer has tested positive for HER2 (a specific protein)
• You have had another type of cancer in the last 5 years, unless it was a certain type of skin cancer or early-stage cervical cancer that has been fully cured
• You have recently received cancer treatments such as chemotherapy, radiation, hormone therapy, biological therapy, immunotherapy, or certain traditional medicines (confirm with trial site for exact timeframes)
• You have had major surgery or a serious injury within 4 weeks before starting the trial, or you are planning to have non-emergency surgery during the trial
• You have significant nerve damage in your hands or feet (Grade 2 or higher), or you previously had serious nervous system side effects from certain cancer drugs
• You have used a drug called capecitabine within the past 6 months, or it did not work well for you in the past, or you were unable to tolerate it
• You have brain tumors that need urgent treatment right now, for example because they are in a dangerous location like the brainstem
• You have cancer that has spread to the thin layers of tissue surrounding the brain and spinal cord
• You are pregnant or breastfeeding
• You have other serious health conditions affecting your heart, kidneys, liver, or other organs that could interfere with treatment
• You are known to be allergic to any of the drugs or ingredients used in this trial
• You are unable to have a brain MRI scan for any reason
• The trial doctor does not think it is appropriate for you to participate
• You are taking or need to take steroid medications (corticosteroids) in certain situations (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.