Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older
• People who have been diagnosed with, or are suspected to have, a type of cancer called squamous cell carcinoma that started in the back of the throat (oropharynx)
• People whose treatment plan involves either surgery to remove the tumour through the mouth plus removal of lymph nodes in the neck, or a combination of radiation therapy and the chemotherapy drug cisplatin — and who are medically suitable for cisplatin even if another drug is used due to supply issues
• People who have had standard scans (chest CT or PET/CT) within the past 16 weeks showing no spread of cancer to distant parts of the body
• People who are generally well and able to carry out normal daily activities with little or no limitation (confirm with trial site for exact fitness level required)
• Women who could become pregnant must have a negative pregnancy test within 7 days before joining
• People who are able to fill in questionnaires on their own or with help
• People who are willing to return to the enrolling hospital for follow-up appointments during the study
• People who are willing to provide blood samples for research, including samples sent for a specific test called NavDx

Who may not be able to join:

• Women who are pregnant or currently breastfeeding
• People of childbearing potential who are not willing to use adequate contraception during the study
• People with serious ongoing illnesses or other severe health conditions that, in the doctor's judgement, would make participation unsafe or affect the reliability of the study results
• People with a weakened immune system, or people known to be HIV positive
• People with uncontrolled health problems such as an active infection, heart failure, unstable chest pain, irregular heartbeat, or mental health or social circumstances that would make it difficult to follow the study requirements
• People currently taking part in another clinical trial for a treatment targeting their cancer
• People who have had another cancer within the past 5 years — with exceptions for certain skin cancers, early-stage cervical cancer, prostate cancer, or localised uterine cancer, provided they are not currently receiving treatment for that cancer (confirm with trial site)
• People who have previously had radiation therapy to the area of the body affected by this cancer
• People who have received chemotherapy within the last 5 years
• People for whom radiation therapy is not considered safe by their treating medical team
• People with a known allergy to the drug docetaxel
• People taking medications that could interfere with the study treatment, such as certain drugs that affect how the body processes chemotherapy (confirm with trial site)
• People with significant pre-existing hearing loss or nerve damage that would, in the doctor's opinion, make cisplatin chemotherapy unsafe
• People whose tumour has been classified as cT4 (a more advanced stage of local tumour growth — confirm with trial site)
• People found after surgery to have no intermediate or high risk features and low-risk disease will be removed from the study and managed under standard care
• People whose cancer tests negative for both HPV and p16 will be removed from the study
• All surgery and chemotherapy must be carried out at the hospital enrolling the patient into the trial

Important: Always verify eligibility with the trial site directly before applying.