Phase 2 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have a mucosal tumour (a tumour on the moist lining of a body cavity) that can be seen on a physical exam or imaging scan.
• People whose cancer has not spread to distant parts of the body.
• People who are already planned to receive a combination immunotherapy treatment (such as ipilimumab and nivolumab, or nivolumab and relatlimab).
• People who are reasonably well and able to carry out some daily activities (confirm with trial site regarding the specific activity level required).
• People aged 18 years or older.
• People of childbearing potential, and their male partners, who agree to use effective contraception throughout the trial and for a set period afterward — acceptable methods include hormonal contraception, an intrauterine device (IUD), surgical sterilisation, vasectomy, or condoms with spermicide; complete abstinence during the trial period is also accepted.
• Men enrolled in the trial who agree to use effective contraception before, during, and for 6 months after completing radiation therapy.
• People who have had or currently have another type of cancer, where that cancer or its treatment is not expected to interfere with safely receiving the treatments in this study.
• People who are able to understand the trial and are willing to sign a written consent form.
• For the sinonasal melanoma group (Arm 1): People who have been confirmed by biopsy or cell testing to have melanoma in the nasal cavity and/or sinuses, who have been assessed by a head and neck surgeon regarding whether surgery is possible, and who are able to have a baseline MRI scan of the skull base (unless there is a medical or financial reason they cannot).
• For the anorectal melanoma group (Arm 2): People who have been confirmed by biopsy or cell testing to have melanoma in the anorectal canal, who have been assessed by a surgical team regarding surgical options, and who are able to have a baseline rectal MRI scan (unless there is a medical or financial reason they cannot).

Who may not be able to join:

• People who have previously had radiation therapy to the area of the body that would be treated in this trial (the nose/sinus area for Arm 1, or the anorectal area for Arm 2).
• People whose cancer has already spread (metastatic disease).
• People who are currently pregnant.
• People under 18 years of age.

Important: Always verify eligibility with the trial site directly before applying.