Phase 1 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to provide written consent to participate before the trial begins
• Women aged 18 years or older
• People who have been confirmed by tissue testing to have a specific type of cervical cancer (squamous cell carcinoma, adenocarcinoma, or adeno-squamous cell carcinoma)
• People whose cervical cancer is classified as FIGO stage II or III (locally advanced, meaning it has spread beyond the cervix but not to distant parts of the body)
• People with no signs that the cancer has spread to other parts of the body
• People who have at least one tumour larger than 5 cm in diameter, confirmed by MRI scan within 28 days before the trial starts, that has not previously been treated with radiation
• People who have not previously received chemotherapy or radiotherapy for cervical cancer
• People who are planned to receive a standard treatment course of external beam radiation therapy (a type of radiation treatment) with 5 cycles of a chemotherapy drug called cisplatin, followed by brachytherapy (internal radiation), all to be completed within 8 weeks of starting
• People with a life expectancy of 3 months or more
• People whose tumour can be safely reached for direct injection of the trial drug
• People with a good general level of physical functioning, rated 0 or 1 on a standard medical scale (meaning fully active or able to carry out light activity) (confirm with trial site)
• Women who could become pregnant must have a negative pregnancy test before starting treatment, and must be willing to use contraception from the time of consent until 3 months after radiation therapy ends

Who may not be able to join:

• People who have had another type of cancer, except for a common, less serious skin cancer called basal cell carcinoma
• People whose cervical cancer has been identified as a rare type, such as small cell (neuroendocrine), melanoma, clear cell, or other uncommon variants
• People who have previously had radiation treatment to the pelvis or abdomen
• People who have previously had their uterus fully or partially removed (hysterectomy)
• People who are planned to have surgery combined with radiation treatment before an operation
• People who are receiving or plan to receive other chemotherapy or cancer treatments beyond the weekly cisplatin specified in the trial
• People whose tumour location or disease extent makes it difficult or unsafe to inject the trial drug directly into the tumour
• People who have medical conditions that make pelvic radiation unsafe, such as inflammatory bowel disease or certain connective tissue disorders
• People who have a medical reason they cannot have an MRI scan
• People who are taking blood-thinning medications or have a blood clotting problem
• People who are pregnant or breastfeeding
• People with serious non-cancer health conditions or active infections that are not under control
• People who have taken part in another clinical trial involving an experimental drug, device, or biological treatment within the past 3 months (observational studies are generally not affected by this rule — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.