Tuberculosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 and older who have been newly diagnosed with tuberculosis (TB) confirmed by laboratory tests — including both drug-sensitive and drug-resistant TB — and who are currently in the early stage of TB treatment, or healthy individuals joining as a comparison group
• People willing to be followed up for four weeks after the second dose of the Pfizer-BioNTech or AstraZeneca COVID-19 vaccine, or for eight weeks after the single-dose Janssen COVID-19 vaccine
• People willing to take part in health checks before the study begins
• Women aged 18–49 who are able to become pregnant and are willing to use effective contraception throughout the study
• Women aged 18–49 who are able to become pregnant and who have a negative pregnancy test both on the day of the initial health check and on the day of vaccination
• People who are able and willing to follow all study requirements
• People who can understand the study instructions and are willing to sign a written consent form

Who may not be able to join:

• People who have previously had COVID-19 confirmed by a laboratory test, or who test positive for COVID-19 at the initial health check
• People with a history of HIV infection
• People already taking part in other COVID-19-related studies during the study period
• People who have taken part in any other vaccine trial within 90 days before or 30 days after the study vaccination
• People who have received any immunoglobulin treatment or any COVID-19 vaccine within the 90 days before the study vaccine is given
• People with a history of allergic reactions that may be triggered by ingredients in the vaccine
• People who have previously had a serious side effect from any vaccine
• People with a history of angioedema (a type of severe swelling under the skin)
• People with a history of anaphylaxis (a severe allergic reaction)
• Women who are pregnant, breastfeeding, or planning to become pregnant during the study
• People currently being diagnosed with or treated for cancer
• People with a history of severe psychiatric disorders that could affect their ability to take part
• People with a bleeding or clotting disorder, a history of blood clots, or a history of significant bleeding or bruising after injections or blood draws
• People with a suspected or known current dependency on alcohol or drugs (unless the condition is well controlled)
• People with any condition that, in the trial doctor's judgement, could put them at undue risk or affect the study results
• People with severe or uncontrolled heart, digestive, liver, kidney, hormonal, or neurological conditions (mild or moderate well-controlled conditions may still be considered — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.