Phase 2 Sickle Cell Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

This trial has three groups. You may qualify for one of them:

Group A – Sickle cell disease with heart stiffness (diastolic dysfunction):

• You are between 18 and 21 years old
• You identify as Black
• You have been diagnosed with sickle cell disease of the HbSS or HbSβ0 thalassemia type (confirm with trial site)
• You have three or more abnormal results on a heart ultrasound test measuring how well your heart relaxes (confirm with trial site)

Group B – Sickle cell disease without heart stiffness:

• You are between 18 and 21 years old
• You identify as Black
• You have been diagnosed with sickle cell disease of the HbSS or HbSβ0 thalassemia type (confirm with trial site)
• You have two or fewer abnormal results on a heart ultrasound test measuring how well your heart relaxes (confirm with trial site)

Group C – Healthy volunteers (no sickle cell disease):

• You are between 18 and 21 years old
• You identify as Black
• You have two or fewer abnormal results on a heart ultrasound test measuring how well your heart relaxes (confirm with trial site)

Who may not be able to join:

• You were hospitalized in the last 4 weeks for a sickle cell pain crisis or a serious lung complication called acute chest syndrome (applies to Groups A and B)
• You received a blood transfusion in the last 3 months (applies to Groups A and B)
• You have any form of sickle cell disease (applies to Group C only)
• You have moderate or severe anemia at your first study visit (applies to Group C only)
• You currently have signs, symptoms, or abnormal heart test results suggesting a heart attack or severe chest pain (unstable angina)
• You have a history of serious abnormal heart rhythms, including ventricular tachycardia, ventricular fibrillation, or supraventricular tachycardia (confirm with trial site)
• You have had heart surgery in the past
• You have a known heart defect present from birth (with the exception of a patent ductus arteriosus or atrial septal defect — confirm with trial site)
• You have narrowing (stenosis) of your heart valves or the main artery supplying your heart
• You have a history of inflammation of the heart muscle or the sac around the heart (myocarditis or pericarditis)
• Your heart's main pumping chamber does not squeeze properly (left ventricle dysfunction)
• You have uncontrolled high blood pressure or a history of a blood pressure emergency
• You have a history of problems with your heart's natural pacemaker or serious blockages in the heart's electrical system (confirm with trial site)
• You have a history of sudden cardiac arrest or cardiac death that was reversed
• You currently have a seizure disorder and are taking anti-seizure medication
• You are pregnant or breastfeeding
• The trial doctors believe, for any medical or personal reason, that joining would not be in your best interest

Important: Always verify eligibility with the trial site directly before applying.