Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with Myelodysplastic Syndrome (MDS) — a bone marrow disorder — classified as intermediate, high, or very high risk based on a standard scoring system used by doctors
• People diagnosed with a condition called CMML-2 (a type of blood cancer) with a white blood cell count below a certain level, confirmed by bone marrow testing
• People diagnosed with a type of acute myeloid leukemia (AML) that developed from a prior bone marrow or blood disorder
• People who, based on local medical standards, are not suitable candidates for a stem cell transplant from a donor
• People for whom a doctor has determined that treatment with a medicine called azacytidine is appropriate, based on local medical guidelines
• People aged between 18 and 80 years old
• People whose liver enzyme levels (ALT, AST), bilirubin, creatinine, and heart enzyme levels are within acceptable ranges as determined by blood tests
• People whose heart pumping function (measured by an ultrasound of the heart) is at or above 50%
• People whose kidneys are filtering at or above a minimum level as measured by a standard calculation
• People who are well enough to carry out daily activities, rated 0–2 on a standard medical scale that doctors use to assess general wellbeing
• People (or their legal representative) who are willing and able to sign a consent form agreeing to take part in the study

Who may not be able to join:

• People diagnosed with certain other blood or bone marrow conditions, including a type of leukemia that is BCR/ABL positive, primary myelofibrosis, polycythemia vera, or essential thrombocythemia
• People with MDS that is classified as low risk on standard scoring systems
• People diagnosed with acute promyelocytic leukemia, myeloid sarcoma, or an advanced phase of BCR/ABL positive chronic myelogenous leukemia
• People who are allergic to any of the medicines used in this study
• People who are pregnant, breastfeeding, or of reproductive age and unwilling to use contraception during the study
• People whose liver or kidney function does not meet the levels required for inclusion
• People with a heart condition causing symptoms or reduced heart function, rated Class 2 or higher on a standard heart health scale
• People currently living with another cancer, unless the other cancer was successfully treated more than 5 years ago with no signs of return, or was a specific type of well-controlled skin cancer or early-stage cervical condition (confirm with trial site for exact details)
• People with a known history of HIV or syphilis, or who have an active Hepatitis B or Hepatitis C infection
• People with serious active heart problems such as uncontrolled irregular heartbeat, heart failure, a heart attack within the past 6 months, or heart disease rated Class 3 or 4 on a standard heart health scale
• People with another medical condition or active infection that may interfere with the study or pose a risk to their participation
• People who are unable to understand or follow the study procedures
• People under 12 years old or over 80 years old
• People who have had major surgery within 4 weeks before joining the trial
• People who are currently taking part in, or have taken part in, another clinical trial within the month before enrolling
• People for whom a matching cord blood stem cell donor cannot be found
• People with a current illegal drug addiction
• People with a mental health condition or cognitive disorder that would affect their ability to participate

Important: Always verify eligibility with the trial site directly before applying.