Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with acute myeloid leukemia (a type of blood cancer), confirmed by laboratory testing, who have not yet received treatment for it, and whose doctors consider standard intensive chemotherapy unsuitable due to age, other health conditions, or personal choice.
• People aged 60 or older, of any sex, with a life expectancy of more than 3 months.
• People whose kidneys are functioning at an adequate level (creatinine clearance of 30 mL/min or above).
• People whose liver function test results are within an acceptable range, as defined by the trial criteria (confirm with trial site).
• People with a general health and activity level rated at 2 or below on a standard medical scale, meaning they are able to care for themselves even if unable to do strenuous activity.
• People who are able to understand the trial information and agree to take part voluntarily.

Who may not be able to join:

• People whose blood cancer is a specific subtype called acute promyelocytic leukemia (APL), or whose cancer has certain low-risk genetic features.
• People whose leukemia has spread to the central nervous system (brain and spinal cord).
• People with a history of certain blood or bone marrow conditions, including myelofibrosis, essential thrombocythemia, polycythemia vera, or chronic myeloid leukemia, or a specific genetic change called BCR-ABL1.
• People who are HIV positive, or who have an active hepatitis B or hepatitis C infection confirmed by blood tests.
• People with serious ongoing conditions affecting the lungs (requiring continuous oxygen), kidneys, nervous system, mental health, hormone systems, immune system, liver, or heart and blood vessels.
• People with conditions that prevent them from absorbing or swallowing oral medication.
• People with certain heart-related issues, including an abnormal heart rhythm reading on an ECG, irregular heartbeat, a heart attack within the past year, heart failure, or coronary heart disease requiring ongoing medication.
• People with a serious, uncontrolled active infection.
• People who have had another cancer within the past 2 years, with some exceptions — such as certain early-stage cervical or breast cancers, basal cell skin cancer, or localised squamous cell skin cancer that have been adequately treated.
• People with a white blood cell count above a certain level, unless this has been brought down with medication or a medical procedure (confirm with trial site).
• People with a mental health condition that would make participation in the trial difficult.
• People who have previously received certain treatments, including hypomethylating agents, venetoclax, chemotherapy for a related blood condition called myelodysplastic syndrome, or a solid organ transplant.
• People whom the trial doctor considers unsuitable for any other reason.

Important: Always verify eligibility with the trial site directly before applying.