Phase 2 Thyroid Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a high-grade brain tumor (WHO grade 4 glioma) that has been confirmed by lab testing, and surgery to remove part or all of the tumor is already planned.
• You have never been treated with a drug called methimazole for this brain tumor.
• You are 18 years of age or older.
• You are well enough to carry out most daily activities (a doctor will assess this using a standard scale).
• Your blood counts, liver function, kidney function, and blood clotting are within acceptable ranges based on tests done within the last 21 days (confirm specific values with trial site).
• If you take blood thinners (such as warfarin), your levels must be stable and within a safe range, with no active or high-risk bleeding.
• Your thyroid function levels are within an acceptable range based on tests done within the last 21 days.
• If you could become pregnant, you must have a negative pregnancy test within the last 21 days, and both you and your partner must agree to use reliable birth control during the trial and for 30 days after the last dose of the study drug.
• You are able to swallow whole tablets.
• Enough time has passed since your last treatment — for example, at least 4 weeks after surgery, 6 weeks after certain chemotherapy drugs, or 2 weeks after other investigational treatments (exact waiting times depend on what treatment you received — confirm with trial site).
• If you are HIV-positive, your virus levels must be undetectable, you must be on a stable HIV treatment regimen, and you must not need preventive antibiotics or antifungal medications.
• If you have or have had hepatitis B, the virus must be undetectable while on appropriate treatment.
• If you have or have had hepatitis C, you must have been successfully treated and cured, or currently be on treatment with an undetectable viral load.
• Your doctor believes you are a suitable candidate for chemotherapy after your surgery.
• You are able to understand the study and are willing to sign a consent form.

Who may not be able to join:

• You still have significant side effects from a previous treatment that have not mostly resolved (exceptions may apply for hair loss or nerve-related symptoms — confirm with trial site).
• You are currently taking part in another clinical trial involving an experimental treatment.
• You have had an allergic reaction to a drug that is chemically similar to methimazole.
• You have an uncontrolled ongoing illness, such as an active infection, serious heart problems, or a mental health or personal situation that would make it difficult to follow the study requirements.
• You have another cancer whose history or treatment could interfere with how this trial measures safety or effectiveness (other prior or current cancers may still be acceptable — confirm with trial site).
• You have a significant ongoing digestive condition that causes frequent or severe diarrhea (such as Crohn's disease or a malabsorption disorder).
• You are pregnant or currently breastfeeding.
• You have a known history of an overactive thyroid (hyperthyroidism) or underactive thyroid (hypothyroidism).
• You are unable or unwilling to swallow tablets.
• You have a serious medical, laboratory, or mental health concern that, in your doctor's judgment, makes this trial unsuitable for you.

Important: Always verify eligibility with the trial site directly before applying.