Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to sign a consent form and are able to follow all the study requirements, including scheduled visits and tests
• You were between 18 and 70 years old when diagnosed
• You have been newly diagnosed with a specific type of nasopharyngeal cancer (a cancer at the back of the nose/throat), confirmed by a tissue sample, of the type called "non-keratinizing carcinoma"
• Your cancer is at a locally advanced stage (meaning it has grown or spread to nearby lymph nodes but not to distant parts of the body), as classified by a standard cancer staging system
• A blood test taken before treatment shows a detectable level of a virus marker called EBV DNA
• You are generally in good physical health and able to carry out daily activities with little or no limitation (confirm with trial site)
• You have not received any treatment for this cancer yet
• Your blood counts are within a healthy range, including white blood cells, neutrophils, hemoglobin, and platelets
• Your liver and kidney are functioning normally, based on blood test results
• If you have hepatitis B, the virus level in your blood must be below a certain threshold at screening; if you have had hepatitis C, the virus must not be detectable at screening
• If you or your partner could become pregnant, you must agree to use reliable contraception from the start of the study until one year after treatment ends

Who may not be able to join:

• Your nasopharyngeal cancer is of a different tissue type, specifically "keratinizing carcinoma" or "basaloid squamous cell carcinoma"
• You have had, or currently have, another type of cancer (with some exceptions such as certain treated skin cancers, cervical carcinoma in situ, or papillary thyroid cancer)
• Your EBV DNA blood marker was undetectable before treatment
• You have had radiation therapy in the past that could overlap with the area to be treated in this trial
• You have already received surgery (other than a diagnostic biopsy), chemotherapy, immunotherapy, or biological therapy for this cancer
• You are currently in another clinical trial involving a treatment intervention
• You have taken high-dose steroid or immune-suppressing medications within the past 28 days
• You have received a live vaccine within the past 30 days
• You have had surgery or a significant injury within the past 30 days
• You have serious or uncontrolled heart problems, such as heart failure, unstable chest pain, a heart attack within the past year, or certain heart rhythm problems
• You have had a stroke within the past 6 months
• You have had a serious active infection in the past 30 days that required treatment with antibiotics, antifungals, or antiviral medicines
• You have an active autoimmune disease (a condition where the immune system attacks the body), with some exceptions such as controlled type 1 diabetes, thyroid conditions managed with hormone replacement, or stable vitiligo
• You have tested positive for HIV, have another immune system disorder, or have had an organ transplant
• You have had a lung inflammation condition (interstitial lung disease or pneumonitis) that required steroid treatment within the past year
• You have active tuberculosis, or had tuberculosis within the past year, or had tuberculosis more than a year ago but did not complete standard treatment
• Your hepatitis B or C virus levels are above the allowed thresholds in blood tests
• You are pregnant or breastfeeding
• You have any other serious condition, including mental health disorders, that the study doctor believes could put you at risk or make it difficult to participate safely

Important: Always verify eligibility with the trial site directly before applying.