Lung Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People whose mediastinal (chest area) tumour has come back, and has been confirmed by a tissue or cell sample test.
• People whose tumour can be physically reached and treated so that at least half of it can be covered by the special radiation seeds used in this trial, as decided by the treating doctor.
• People who have up to two tumours that could be treated.
• People whose case has been reviewed and approved for this type of internal radiation treatment by a team of specialists.
• People whose tumour can be measured using standard imaging guidelines (called RECIST 1.1).
• People whose tumour is no larger than 3 cm at its widest point.
• People aged 18 or older.
• People who are well enough to carry out basic daily activities, as measured by a standard health scale (ECOG score of 3 or below — confirm with trial site for what this means in practice).
• People who have a life expectancy of more than 6 months.
• People whose blood cell counts and kidney and liver function meet specific minimum levels set by the trial (the trial site will check these through blood tests).
• People whose blood clotting level (INR) is below 1.4, if they are not taking the blood-thinning medication Warfarin.
• People who are willing and able to sign a consent form agreeing to take part.
• Women who could become pregnant must have a negative pregnancy test before treatment and must use an accepted method of contraception for 3 months after the radiation procedure.

Who may not be able to join:

• People who are currently receiving chemotherapy or immunotherapy at the same time.
• People who have cancer that has spread to the brain.
• People who have a connective tissue disease such as scleroderma or lupus.
• People who have a known allergy or sensitivity to any component of the treatment.
• People who are taking ongoing medication that suppresses the immune system, except for short, occasional courses of corticosteroids.
• People with serious heart or cardiovascular conditions, such as severe heart failure, uncontrolled coronary artery disease, uncontrolled irregular heartbeat, uncontrolled high blood pressure, or a heart attack within the past 12 months.
• People with other serious uncontrolled health conditions, including active infections requiring treatment, or psychiatric or substance use conditions that could interfere with taking part in the trial.
• People who have another cancer that is currently growing or needs active treatment (with some exceptions such as certain treated skin cancers or early-stage cervical cancer — confirm with trial site).
• People who need treatments outside of what this trial allows, which could affect how results are measured.
• People who are not willing or able to use an adequate method of contraception before, during, and for 3 months after the trial treatment (this applies to all participants, not only women).
• People who have taken part in another interventional clinical trial in the past 30 days, if that trial could affect this trial's results.
• People who, in the opinion of the trial investigators, are unlikely to be able to follow the trial's requirements.
• Women who are breastfeeding, or women who could become pregnant but are unwilling or unable to use an accepted contraceptive method for 3 months after treatment.

Important: Always verify eligibility with the trial site directly before applying.