Phase 2 Sickle Cell Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged 12 years or older
- People who have already been diagnosed with sickle cell disease (specific types include Hb SS, Hb SC, Hb Sβ+, and Hb Sβ0)
Who may not be able to join:
- People who are currently pregnant or breastfeeding
- People who have previously received gene therapy or a stem cell transplant
- People who are currently enrolled in another clinical trial involving a drug or biologic regulated by the FDA
- People who currently have a low neutrophil count (a type of white blood cell) — (confirm with trial site)
- People who currently have a low platelet count — (confirm with trial site)
- People whose liver enzyme levels (AST or ALT) are significantly higher than normal — (confirm with trial site)
- People with a history of tuberculosis (TB)
- People who have tested positive on a standard TB screening test
- People currently being treated with certain targeted therapy drugs, including Acalabrutinib, Ibrutinib, or Zanubrutinib
- People currently being treated with certain other targeted therapy drugs, including Baricitinib, Ruxolitinib, Tofacitinib, or Upadacitinib
- People who have received any of a specific list of immune-suppressing biologic medications within the past 6 months — this includes drugs such as Rituximab, Adalimumab, Infliximab, Pembrolizumab, Nivolumab, Tocilizumab, and many others (confirm with trial site for the full list)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Austin Wesevich, MD, University of Chicago
Phone: 773-834-6732
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Time-weighted SaO2/FiO2 ratio
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.