Phase 2 Non-Alcoholic Fatty Liver Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For healthy adults (Part A):

• You are between 18 and 55 years old
• You have a body mass index (BMI) — a measure of body weight relative to height — between 18 and 32
• A doctor has reviewed you and considers you to be in good health
• Your recent blood test results are within a healthy range

For Japanese participants in the healthy adult group only:

• You were born in Japan, both of your biological parents and all four biological grandparents are ethnically Japanese and were born in Japan
• You have maintained a Japanese lifestyle and diet since leaving Japan
• You have been living outside of Japan for fewer than 10 years

For adults with a specific liver condition called MASLD (Parts B and C):

• You are between 18 and 65 years old (Part B) or 18 and 75 years old (Part C)
• If you are of East Asian background (e.g. Chinese, Japanese, South Korean, Taiwanese), your BMI is between 23 and 40; for all other backgrounds, your BMI is between 27 and 40
• A special type of liver scan (MRI) shows that at least 8.5% of your liver is made up of fat

Who may not be able to join:

For healthy adults (Part A):

• You have a significant history of heart, lung, liver, kidney, digestive, hormonal, blood, mental health, nerve, or skin conditions that could affect the study
• You have been in hospital for any reason within the past 30 days
• Your kidney filtering function falls below a certain level (confirm with trial site)
• Your blood test results show that certain liver-related values — ALT, AST, or bilirubin — are above the normal range
• You currently smoke or use e-cigarettes, or you stopped smoking within the last 3 months
• You have a history of alcohol or drug misuse, in the opinion of the study doctor
• You have tested positive for Hepatitis C antibodies and also have an active Hepatitis C virus infection

For adults with MASLD (Parts B and C):

• You have another known long-term liver disease
• You are unable to have an MRI scan for any reason (e.g. a pacemaker or metal implants — confirm with trial site)
• You have a history of Type 1 diabetes
• Your body weight has changed by more than 4% (either gained or lost) in the 3 months before or during the screening period
• You have HIV, an active or ongoing Hepatitis B infection, or an active or ongoing Hepatitis C infection
• You have had weight-loss (bariatric) surgery within the past 5 years (Part B) or 3 years (Part C), or you are planning to have it during the study

Important: Always verify eligibility with the trial site directly before applying.