Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 years or older who are not suitable for a standard intensive treatment protocol (called the STUPP protocol), and who fall into one of two groups:
  • Group 1: People aged 18–70 who cannot have surgery, have a functioning level score (Karnofsky Index) of 50% or above at the time of joining, and have biopsy results available
  • Group 2: People over 70 who have been assessed as relatively fit for their age (Balducci score I or II), have a functioning level score of 60% or above, and have had either a partial surgical removal of the tumour or a biopsy result available
• People who have been confirmed through tissue testing to have glioblastoma (a type of brain tumour)
• People whose brain scan (a specialised PET scan using a tracer called FDOPA) shows increased activity in the tumour area, which allows doctors to map the treatment zone

Who may not be able to join:

• People who are considered suitable for the standard intensive treatment protocol (the STUPP protocol)
• People for whom MRI or PET scanning is not safe or suitable (for example, due to certain implants or allergies)
• People where the planned radiation treatment area falls less than 2 cm from the optic chiasm or optic nerves (structures involved in vision)
• People whose FDOPA PET scan does not show the expected tracer uptake in the tumour area

Important: Always verify eligibility with the trial site directly before applying.