Tuberculosis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• The trial takes place at primary care clinics in KwaZulu-Natal, Gauteng, and Eastern Cape provinces in South Africa that fall within selected hospital areas
• The clinics involved must have the support of provincial TB program managers, hospital leadership, and the clinic's nurse manager
• The clinics must see 10 or more patients diagnosed with drug-resistant TB per year and have access to laboratory testing, X-ray, and ECG (heart tracing) equipment
• Participants must be adults aged 18 or older, regardless of HIV status
• Participants must have a new diagnosis of rifampicin-resistant TB (a form of drug-resistant TB)
• Participants must be able to give informed consent in one of four languages: Zulu, Xhosa, Afrikaans, or English

Who may not be able to join:

• People whose condition requires a hospital stay rather than treatment at an outpatient clinic — for example, those with severe weakness, confusion, severe mental illness, very low blood pressure, severe difficulty breathing, or a temperature above 39°C
• People with a very low red blood cell count (haemoglobin below 8mg/dL) or signs of liver damage based on blood test results
• People whose heart electrical activity shows a prolonged interval (QTc above 470ms), confirmed by two or more ECG (heart tracing) tests
• People with a very fast heart rate (above 140 beats per minute) that remains after five minutes of rest
• People who are pregnant
• People who show signs that the TB infection has spread outside the lungs
• People already enrolled in another clinical trial that changes the treatment plan, its length, or how symptoms are managed

Important: Always verify eligibility with the trial site directly before applying.