Coeliac Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

This trial has three separate groups, each with different requirements:

Gluten Challenge Group (people with celiac disease who eat gluten-free):

• You are between 18 and 75 years old
• You were diagnosed with celiac disease by an intestinal biopsy at least 12 months ago
• You have been strictly following a gluten-free diet for at least the past 12 months in a row

Gluten De-challenge Group (people with celiac symptoms not on a gluten-free diet):

• You are between 18 and 75 years old
• You are currently experiencing typical celiac disease symptoms
• You are not currently following a gluten-free diet

Control Group (general participants):

• You are between 18 and 75 years old
• If you are female, you are not currently pregnant

Who may not be able to join:

Gluten Challenge Group:

• You have been diagnosed with a serious complication of celiac disease
• You have another long-term, active digestive or gut disease
• You have a specific immune system condition affecting a protein called IgA (confirm with trial site)
• You have had a severe reaction after being exposed to gluten
• You have any other significant health conditions
• You have a history of serious alcohol or substance misuse
• You are pregnant or breastfeeding
• You have a blood clotting disorder

Gluten De-challenge Group:

• You have a history of long-term inflammatory gut disease
• You have had a gut or stomach illness in the four weeks before screening
• You have a history of a condition affecting certain blood or lymph cells (confirm with trial site)
• You have an uncontrolled blood clotting disorder
• You have any other significant health conditions
• You have a history of serious alcohol or substance misuse

Control Group:

• You are currently taking antibiotics, stomach acid-reducing medication (such as omeprazole), aspirin, or anti-inflammatory painkillers (such as ibuprofen)
• You have a known condition causing inflammation in your gut or intestines
• You have previously had surgery on your digestive system
• You are taking blood-thinning or anti-clotting medications
• A close family member has been diagnosed with celiac disease

Important: Always verify eligibility with the trial site directly before applying.