Phase 1 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been previously diagnosed with a high-grade brain tumour called glioblastoma or anaplastic astrocytoma, and whose brain scans show signs that the tumour has come back or grown
• People who are 18 years of age or older and are able to give informed consent and commit to the full requirements of the study
• People whose tumour has come back at least 3 months after finishing radiation therapy, at least 4 weeks after finishing most types of chemotherapy, or at least 6 weeks after finishing a specific type of chemotherapy called nitrosourea
• People who have recovered from most side effects of previous treatments (side effects must be mild or resolved)
• People whose tumour can be partially or fully removed through surgery, as determined by a specialist medical team including neurosurgeons, radiation specialists, and brain tumour doctors
• People whose surgical cavity after tumour removal is not expected to connect to the fluid-filled spaces in the brain (ventricles)
• People with a general health and functioning score of 60 or above on a standard medical scale called the Karnofsky Performance Status at the time of surgery
• People who have not previously had gene therapy, virus therapy, immunotherapy, radiation implants, or chemotherapy implants (such as Gliadel Wafers) used to treat this tumour
• People with no immune system disorders and who are not on immune-suppressing medications
• People with blood test results within acceptable ranges, including kidney function, blood cell counts, and liver function, measured within 30 days before starting the study
• Women who could become pregnant must agree to use contraception throughout treatment and for at least 90 days after surgery; men must use barrier contraception during treatment and for at least 90 days after surgery

Who may not be able to join:

• People with an active infection (such as a viral, bacterial, or fungal infection) that has required treatment and caused a high fever or significant changes in white blood cell counts
• People who test positive for HIV antibodies
• People with a history of liver disease, including autoimmune or viral hepatitis
• People who test positive for Hepatitis B or Hepatitis C
• People currently taking immune-suppressing medications (corticosteroids are an exception)
• People with serious medical or mental health conditions, or who are taking other medications, that the medical team believes could interfere with their ability to participate in or tolerate the trial
• People with weakened immune systems or who are particularly vulnerable to serious viral infections
• People who are pregnant or breastfeeding
• People with known allergies to any product used in this trial
• People who are unable to have a brain MRI scan
• People whose tumour cannot be surgically removed

Important: Always verify eligibility with the trial site directly before applying.