Early Phase 1 Kidney Cancer Trial, Recruiting NCT05702398 Sponsor: Rhode Island Hospital Condition: Kidney Cancer
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Early Phase 1 Kidney Cancer Trial, Recruiting

NCT05702398
Recruiting Early Phase 1

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged 18 years or older
  • People who have had 2 or more skin cancers (specifically a type called squamous cell carcinoma, confirmed by a skin sample/biopsy) in the past 2 years, OR who have had a medical procedure recorded for the removal or destruction of 15 or more skin lesions that were either benign (non-cancerous) or pre-cancerous
  • People who can read, write, and understand English proficiently

Who may not be able to join:

  • People with liver disease
  • People with an active stomach ulcer (peptic ulcer disease)
  • People who have recently had a heart attack
  • People with low blood pressure (hypotension)
  • People who have had a cancer inside the body (not on the skin) within the past 5 years
  • People with significantly reduced kidney function (confirm with trial site for specific test values)
  • People who would not be able to attend follow-up appointments due to personal or social circumstances
  • People with Gorlin's syndrome or another inherited (genetic) skin cancer condition
  • People with a very large number of current skin cancers (confirm with trial site for specific threshold)
  • People who have had a spreading (metastatic) skin squamous cell carcinoma, or an invasive melanoma, within the past 5 years
  • People who are pregnant or breastfeeding
  • People who need to continue taking the medication carbamazepine (used for conditions such as epilepsy or nerve pain)
  • People who have used acitretin or similar oral medications (oral retinoids) within the past 6 months
  • People who have taken supplement forms of NAM (nicotinamide), niacin, vitamin A, or beta carotene within the past 6 months
  • People who have had a field treatment for pre-cancerous skin lesions (actinic keratoses) within the past 4 weeks
  • People who are currently using topical (applied to the skin) steroid creams or ointments

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 13 July 2026
Early Phase 1 studies are small, early exploratory studies that come before the main Phase 1 to 3 testing, so a standard phase success rate does not apply.

Contact this trial

Phone: 401-863-5895

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Early Phase 1
Sponsor
Rhode Island Hospital
Registry
ClinicalTrials.gov
Start date
1 April 2023
Est. completion
1 January 2028

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change of Blood Vitamin A and Nicotinamide Levels

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 13 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov