OCD Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 55 years old
- You score 90 or higher on a questionnaire that measures how difficult it is for you to manage your emotions (called the DERS scale)
- You have been doing the same type of talk therapy (or no therapy at all) for the past month, and are willing to keep it the same throughout the study (note: if you are currently doing CBT — a specific type of talk therapy — this may affect eligibility; confirm with trial site)
- You score below a certain level on a questionnaire measuring how often you use a mental technique called "cognitive restructuring" to handle emotions
- You have been diagnosed with at least one condition such as a mood disorder, anxiety disorder, OCD, ADHD, an impulse control disorder, an eating disorder, or a stress-related disorder — this can include conditions that are currently active or partially in remission (confirm with trial site for specific diagnoses)
- If you take any psychiatric medications, you have been on a stable dose for at least the past 4 weeks and are willing to keep the dose the same during the study
- You have never had a treatment called rTMS (a type of brain stimulation) before
Who may not be able to join:
- You are currently experiencing a hypomanic episode (a period of unusually high or energetic mood)
- You currently have, or have a history of, a psychotic disorder or psychotic symptoms (such as hallucinations or delusions)
- You have been diagnosed with Bipolar I disorder
- You currently have, or have a history of, a moderate or severe alcohol or substance use disorder (confirm with trial site for exact criteria)
- You are unable to read, are blind or deaf, or are unwilling to give your consent to participate
- You are not an English speaker
- Your verbal IQ score is below 90 on a specific reading-based test (confirm with trial site)
- You currently have uncontrolled anorexia or any other condition that requires you to be in hospital
- You are considered at high risk for suicide, meaning you have attempted suicide in the past 6 months, or you are currently having thoughts of suicide that include a specific method, plan, or intention
- You have a serious medical illness, including severe migraine headaches
- You have started or changed psychiatric medications in the past 4 weeks, or plan to change them during the study
- You have a history of seizures (except seizures caused by a medical treatment called ECT, or childhood febrile seizures), epilepsy in yourself or a close blood relative, stroke, brain surgery, significant head injury, metal implants in your skull, known brain lesions, or certain medical devices in your body such as a pacemaker, cochlear implant, medication pump, or implanted brain stimulator
- You have tendonitis in your left elbow, hand, or wrist
- You have certain brain or neurological conditions such as dementia, Parkinson's disease, Huntington's disease, multiple sclerosis, a history of a mini-stroke (TIA), a brain aneurysm, or significantly raised pressure inside the skull (confirm with trial site)
- You take Wellbutrin (bupropion) at more than 300mg per day, or take daily stimulant or ADHD medications above the maximum recommended daily dose
- You have used an experimental drug or device within the past 4 weeks
- You have a cochlear implant
- You are pregnant
- You have metal in your body that would prevent you from having an MRI scan, or you have severe claustrophobia (fear of enclosed spaces)
- You are currently a prisoner, in police custody, or have a court case that could interfere with your participation in the study
- You have ever had TMS (brain stimulation) treatment at any point in your life
- You have had CBT (a specific type of talk therapy) in the past 4 weeks, or plan to start any new therapy during the study
- You weigh over 300 pounds (due to MRI scanner size limitations)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Andrada D Neacsiu, PhD, Duke University
Phone: 9196846785
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
High Frequency Heart Rate Variability (HF-HRV) during regulation blocks during the neurostimulation day; Time to return to Heart Rate (HR) baseline measured during regulation period; Change in the ventrolateral prefrontal cortex (vlPFC) for the [restructure-flow_negative] contrast; Change in the dorsomedial prefrontal cortex (dmPFC) for the [restructure-flow_negative] contrast; Change in the ventromedial prefrontal cortex (vmPFC) for the [restructure-flow_negative] contrast; Change in the insular cortex for the [restructure-flow_negative] contrast; Change in dorsolateral prefrontal cortex (dlP...
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.