Phase 3 Rare Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a locally advanced or metastatic cancer (either a solid tumour or a blood cancer) that has been confirmed by a tissue test, and either standard treatments have stopped working, you have chosen not to have standard treatments, or no effective standard treatment exists for your cancer.
• Your cancer is either a rare type, or a more common cancer type that has a rare specific genetic change, and that genetic change has been identified using a specialist gene-sequencing test, with a matching treatment option available within this trial.
• Your doctors estimate you have a life expectancy of at least three months.
• You are able to give written consent to take part and are able to cooperate with the treatment and follow-up visits (for those under 16, a parent or legal guardian must give written consent, and the young person will be asked to agree in an age-appropriate way).
• Your cancer can be measured or assessed to track how it is responding to treatment.
• You are willing and able to provide a fresh tissue sample (biopsy) and blood samples at the start of the trial for research purposes (different sample types may apply for blood cancers or certain other tumour types — confirm with trial site).
• You are well enough to carry out your daily activities to a level that meets the trial's fitness standards (measured using standard medical scoring tools appropriate for your age group — confirm details with trial site).
• If you are a woman who could become pregnant, you must have a negative pregnancy test before joining and agree to use appropriate contraception as specified by the trial.
• If you are a man whose partner could become pregnant, you must agree to use appropriate contraception as specified by the trial.

Who may not be able to join:

• You are still experiencing significant side effects (grade 2 or above) from previous cancer treatments, unless your doctor considers them stable and not a reason to exclude you.
• You have a serious non-cancer-related health condition, including an active uncontrolled infection, that your doctor feels puts you at high medical risk.
• You are pregnant, breastfeeding, or planning to become pregnant during the trial or shortly after, or you are a man whose partner is planning to become pregnant during the trial or shortly after the last dose of the trial treatment.
• You are currently taking part in, or plan to join, another clinical trial that involves receiving an experimental treatment at the same time (taking part in an observation-only study, such as a quality-of-life survey or sample collection study, may be acceptable — confirm with trial site).
• You are receiving other anti-cancer treatments at the same time, with the exception of certain long-term hormone treatments (such as those used in prostate cancer — confirm with trial site).
• You have received certain cancer treatments — including radiotherapy (other than for pain relief), chemotherapy, immunotherapy, or targeted therapies — within the past four weeks or within five half-lives of the treatment (whichever is shorter).
• You have brain metastases (cancer that has spread to the brain) that are rapidly getting worse or causing worsening symptoms; previously treated and stable brain metastases may be acceptable under certain conditions — confirm with trial site.
• You have any other health condition that your doctor believes means taking part would not be in your best interests.

Important: Always verify eligibility with the trial site directly before applying.