Phase 2 PTSD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 21 and 70 years old (male or female).
• If you are a woman who could become pregnant, you agree to use an accepted form of birth control, or you are post-menopausal for at least 1 year, or have had a surgical procedure that prevents pregnancy.
• You do not have a medical or brain condition, and are not taking a medication, that would make the study drug (ketamine) unsafe for you.
• You have been diagnosed with chronic PTSD with a severe score (25 or higher) on a standard PTSD assessment scale, and your PTSD symptoms have lasted more than 1 year since the traumatic event.
• If you are currently taking certain approved antidepressants or related medications, you have been on a stable dose for at least 4 weeks before joining.
• You are able to read, write, and give your consent in English.

Who may not be able to join:

• You have a diagnosis of borderline personality disorder, obsessive-compulsive disorder, schizophrenia, schizoaffective disorder, or dementia, or you are currently showing signs of psychosis.
• You have bipolar disorder and have had a manic or hypomanic episode within the past 30 days.
• You have a history of mania or hypomania caused by antidepressant medication.
• You are currently considered to be at serious risk of suicide, based on a standard assessment.
• You have had a moderate or severe substance use disorder (not including alcohol or marijuana) in the past 3 months.
• You are currently taking a medication on the study's prohibited list — including certain antidepressants called MAOIs, memantine, or certain long-acting benzodiazepines — and have not been off them for the required amount of time (confirm with trial site).
• You have had a serious traumatic brain injury with a loss of consciousness for more than 24 hours or memory loss for more than 7 days, unless it happened more than 1 year ago and you have had minimal symptoms since (confirm with trial site).
• You have a positive pregnancy test at any point during the study, or you are breastfeeding.
• You have any alcohol in your system at screening or before receiving the study drug.
• Your resting blood pressure is below 90/60 or above 150/90, or your resting heart rate is below 45 or above 100 beats per minute.
• You have a significant history of serious medical or neurological illness.
• Tests such as an ECG, physical exam, or lab work show signs of a major medical or neurological condition.
• You test positive for drugs on a urine drug screen at screening.
• You have a known learning disability or intellectual disability.
• You have a known allergy or sensitivity to ketamine.
• Your body circumference is 52 inches or more, or you weigh 350 pounds or more.
• You have a history of claustrophobia (fear of enclosed spaces).
• You have a pacemaker, other electronic implant, or metal objects in your body that would make an MRI scan unsafe.
• You have donated more than 500 mL of blood in the 56 days before starting the study.
• You have a history of sensitivity to heparin (a blood-thinning medication) or a related blood disorder.
• You have recently started (within the past 3 months) a structured, trauma-focused therapy such as CBT, CPT, PE, or EMDR for PTSD.
• You are currently enrolled in, or recently joined (within the past 2 months), another research study testing an experimental treatment.

Important: Always verify eligibility with the trial site directly before applying.